A testis antigen related to the brain D2 adhesion protein.
The localization of an antigen immunochemically crossreactive with the rat brain interneuronal adhesion molecule, D2-protein, has in testis been demonstrated by immunoelectrophoresis and immunocytochemistry. This D2-like antigen is localized to spermatids and residual bodies in testis, but it is absent both from spermatogonia and mature spermatozoa and from Sertoli cells. By immunoperoxidase electronmicroscopy D2-like antigen was observed in the head region posterior to the acrosomal membrane of late spermatids. In the nervous system D2-protein is involved in interneuronal adhesion. It is suggested that D2-like antigen in testis may be involved in a similar adhesion between late spermatids and Sertoli cells during spermiation.[1]References
- A testis antigen related to the brain D2 adhesion protein. Jørgensen, O.S., Møller, M. Dev. Biol. (1983) [Pubmed]
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