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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

(3H)-spiroperidol binding sites in the rabbit splenic artery.

The topographic distribution of (3H)-spiroperidol binding sites (corresponding to dopamine receptors likely) was studied in rabbit splenic artery by the use of a histoautoradiographic technique. (3H)-spiroperidol was localized preferentially at the level of smooth muscle cells of the media as well as in close relation with cellular membrane of endothelial cells. The findings of a constant distribution of (3H)-spiroperidol binding sites within the medial layer of the splenic artery led us to hypothesize that these receptors mediate the relaxation of the splenic artery determined by dopamine infusion.[1]


  1. (3H)-spiroperidol binding sites in the rabbit splenic artery. Amenta, F., Cantagalli, A., Cavallotti, C., Mione, M.C., Sancesario, G. Basic Res. Cardiol. (1984) [Pubmed]
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