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MeSH Review

Splenic Artery

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Disease relevance of Splenic Artery


High impact information on Splenic Artery

  • When the stomach was stimulated by bethanechol infusion through the splenic artery, as in the human stomach, the manometry detected less than 50% of gastric contractions detected by the strain gauge recording [2].
  • Study group B (6 dogs): (1) ATS, (2) ATS + S + the beta adrenergic agonist, isoproterenol, 1.5 microng per kg-min infused into the splenic artery, and (3) ATS + S + TC + isoproterenol [6].
  • Patients were divided retrospectively into two groups: G1 (n = 7), without modulation of rPVF, and G2 (n = 10), with splenic artery ligation to decrease rPVF perioperatively [7].
  • L-NMMA (10(-4) M) partially inhibited the ADM-induced relaxation in splenic arteries (maximal relaxation: 38 +/- 3 (ADM + L-NMMA, n = 5) vs. 60 +/- 3 % (ADM + D-NMMA, n = 5), P < 0.05) [8].
  • 2. ANF, infused into the splenic artery of anaesthetized rats at rates of 1, 5 and 20 ng min -1, caused a dose-dependent increase in the arteriovenous difference in haematocrit as blood flowed through the spleen (basal difference, 0.18 +/- 0.10%; difference after 10 min at 20 ng min -1 ANF, 1.5 +/- 0.18%; n = 6) [9].

Chemical compound and disease context of Splenic Artery


Biological context of Splenic Artery


Anatomical context of Splenic Artery


Associations of Splenic Artery with chemical compounds


Gene context of Splenic Artery

  • There was no significant difference between the liver, splenic artery and vein in the expression of local renin or local angiotensinogen mRNA in PH group, (P<0.05) [28].
  • 4. In conclusion, enhanced contractile responses to UK14304 and NPY in the porcine splenic artery can be uncovered using methods similar to those employed in the porcine ear artery [19].
  • Dog splenic artery strips were incubated with [3H]NA after inhibition of catechol-O-methyl-transferase (COMT) and of extraneuronal uptake [29].
  • SUBJECTS AND METHODS: In addition to static T1- and T2-weighted MR imaging, MRAP was performed immediately after hepatic angiography through contrast material injection into intraarterially placed catheters (superior mesenteric or splenic artery) in 21 patients with nodular hepatocellular carcinoma [30].
  • Anomalies of the celiac trunk and SMA, more common than previously claimed, include the splenic artery arising from the SMA, which occurs in only 1% of patients [31].

Analytical, diagnostic and therapeutic context of Splenic Artery

  • BACKGROUND: Japanese surgeons have been actively performing extended lymphadenectomy (D2, removal of perigastric nodes and nodes along the left gastric, common hepatic, celiac and splenic arteries; or D3, D2 plus removal of nodes in the hepatoduodenal ligament, in the retropancreatic space and along the vessels of the transverse mesocolon) [32].
  • RESULTS: Expression of local renin mRNA in the liver of control group was (0.19+/-0.11), significantly lower than that in splenic artery (0.45+/-0.17) or splenic vein(0.39+/-0.12) respectively, (P<0.05) [28].
  • To test this hypothesis with a new animal model, we injected 20 microns polystyrene microspheres retrogradely into the distal splenic artery of rats, thus incompletely blocking blood perfusion in the splenic portion of the pancreas [33].
  • Polystyrene microspheres 5 micron in diameter and Indian ink, consisting of particles 0.03 micron in diameter, were injected into the splenic artery in rats [34].
  • The tumor region was heated to 43 degrees C-45 degrees C for up to 60 min, while 5-FU 500 mg was injected simultaneously through the gastroduodenal artery into the splenic artery (intraoperative regional chemotherapy) [35].


  1. Massive splenic infarction in cirrhosis: report of a case with spontaneous disappearance of hypersplenism. Capron, J.P., Chivrac, D., Dupas, J.L., Rémond, A., Ossart, J.L., Lorriaux, A. Gastroenterology (1976) [Pubmed]
  2. Study of electromechanical activity of the stomach in humans and in dogs with particular attention to tachygastria. You, C.H., Chey, W.Y. Gastroenterology (1984) [Pubmed]
  3. Treatment of refractory splenomegaly in myeloproliferative disease by splenic artery infusion. Canellos, G.P., Sutliffe, S.B., DeVita, V.T., Lister, T.A. Blood (1979) [Pubmed]
  4. Splenic implants: evaluation with radionuclide methods. Abu-Nema, T., Nawaz, K., Sadek, S., Ayyash, K., Tibblin, S., Al-Mohannadi, S., Abdel-Dayem, H.M. Radiology. (1987) [Pubmed]
  5. Foregut revascularization via retrograde splenic artery perfusion after resection of a juxtaceliac mycotic aneurysm: complicated by pancreatic infarction because of cholesterol emboli. Hashemi, H.A., Comerota, A.J., Dempsey, D.T. J. Vasc. Surg. (1995) [Pubmed]
  6. Influence of isoproterenol and cholestyramine on acute gastric mucosal ulcerogenesis. Ritchie, W.P., Shearburn, E.W. Gastroenterology (1977) [Pubmed]
  7. Modulation of portal graft inflow: a necessity in adult living-donor liver transplantation? Troisi, R., Cammu, G., Militerno, G., De Baerdemaeker, L., Decruyenaere, J., Hoste, E., Smeets, P., Colle, I., Van Vlierberghe, H., Petrovic, M., Voet, D., Mortier, E., Hesse, U.J., de Hemptinne, B. Ann. Surg. (2003) [Pubmed]
  8. Adrenomedullin increases fluid extravasation from the splenic circulation of the rat. Kaufman, S., Andrew, P., Sultanian, R., Deng, Y. J. Physiol. (Lond.) (2001) [Pubmed]
  9. Influence of atrial natriuretic factor on fluid efflux from the splenic circulation of the rat. Deng, Y., Kaufman, S. J. Physiol. (Lond.) (1996) [Pubmed]
  10. Splenic artery ligation in experimental hypersplenism. Witte, C.L., Corrigan, J.J., Witte, M.H., O'Mara, R.E. Surgery (1976) [Pubmed]
  11. Splenic infarction complicated by splenic artery occlusion after N-butyl-2-cyanoacrylate injection for gastric varices: case report. Yu, L.K., Hsu, C.W., Tseng, J.H., Liu, N.J., Sheen, I.S. Gastrointest. Endosc. (2005) [Pubmed]
  12. Temporary spontaneous thrombosis of a splenic artery pseudoaneurysm in chronic pancreatitis during intravenous octreotide administration. Tang, L.J., Zipser, S., Kang, Y.S. Journal of vascular and interventional radiology : JVIR. (2005) [Pubmed]
  13. Polyvinyl alcohol and gelatin sponge particle embolization of splenic artery pseudoaneurysm complicating chronic alcoholic pancreatitis. Guan, Y.S., Sun, L., Zhou, X.P., Li, X., Fei, Z.J., Zheng, X.H., He, Q. World J. Gastroenterol. (2005) [Pubmed]
  14. Site of analgesic action of zomepirac sodium, a potent non-narcotic analgesic in experimental animals. Nakamura, H., Imazu, C., Ishii, K., Yokoyama, Y., Kadokawa, T., Shimizu, M. Jpn. J. Pharmacol. (1983) [Pubmed]
  15. Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2,2'-pyridylisatogen tosylate. Ren, L.M., Burnstock, G. Br. J. Pharmacol. (1997) [Pubmed]
  16. Pharmacological evidence for the presence of a peripheral postjunctional D2-like dopamine receptor in rabbit splenic artery. Zanzottera, D., Ferlenga, P., Marchini, F., Semeraro, C. Br. J. Pharmacol. (1998) [Pubmed]
  17. (3H)-spiroperidol binding sites in the rabbit splenic artery. Amenta, F., Cantagalli, A., Cavallotti, C., Mione, M.C., Sancesario, G. Basic Res. Cardiol. (1984) [Pubmed]
  18. Pseudocyst in splenic hilus with splenic vein thrombosis. Case presentation and review. Engel, A., Adler, O.B., Keidar, S. European journal of radiology. (1987) [Pubmed]
  19. alpha(2)-adrenoceptor and NPY receptor-mediated contractions of porcine isolated blood vessels: evidence for involvement of the vascular endothelium. Roberts, R.E., Kendall, D.A., Wilson, V.G. Br. J. Pharmacol. (1999) [Pubmed]
  20. Dopamine receptors in human basilar arteries. Forster, C., Drew, G.M., Hilditch, A., Whalley, E.T. Eur. J. Pharmacol. (1983) [Pubmed]
  21. Different characteristics of postjunctional alpha-adrenoceptors on arterial and venous smooth muscle. Hieble, J.P., Woodward, D.F. Naunyn Schmiedebergs Arch. Pharmacol. (1984) [Pubmed]
  22. Potentiation of the effects of dopamine in the rabbit isolated splenic artery by 3-isobutyl-1-methylxanthine or forskolin. Clark, K.L., Drew, G.M., Hilditch, A. Naunyn Schmiedebergs Arch. Pharmacol. (1989) [Pubmed]
  23. Surgical implications of the posterior gastric artery. Yu, W., Whang, I. Am. J. Surg. (1990) [Pubmed]
  24. Technetium-99m sulfur colloid spleen imaging following partial pancreatectomy and splenic artery and vein resection. Kuni, C.C., Crass, J.R., duCret, R.P., Boudreau, R.J., Loken, M.K. J. Nucl. Med. (1989) [Pubmed]
  25. Effects of a selective neuropeptide Y Y(1) receptor antagonist BIBP 3226 on double peaked vasoconstrictor responses to periarterial nerve stimulation in canine splenic arteries. Yang, X.P., Chiba, S. Br. J. Pharmacol. (2000) [Pubmed]
  26. Existence of different alpha(1)-adrenoceptor subtypes in junctional and extrajunctional neurovascular regions in canine splenic arteries. Yang, X.P., Chiba, S. Br. J. Pharmacol. (2001) [Pubmed]
  27. An unusual Ca(2+) entry pathway activated by protein kinase C in dog splenic artery. Khoyi, M.A., Gregory, L.G., Smith, A.D., Keef, K.D., Westfall, D.P. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  28. Expression of local renin and angiotensinogen mRNA in cirrhotic portal hypertensive patient. Zhang, L., Yang, Z., Shi, B.M., Li, D.P., Fang, C.Y., Qiu, F.Z. World J. Gastroenterol. (2003) [Pubmed]
  29. The influence of monoamine oxidase activity on the release of noradrenaline by tyramine. Brandão, F., Araújo, D., Monteriro, J.G. J. Pharm. Pharmacol. (1989) [Pubmed]
  30. MR imaging during arterial portography for assessment of hepatocellular carcinoma: comparison with CT during arterial portography. Yu, J.S., Kim, K.W., Lee, J.T., Yoo, H.S. AJR. American journal of roentgenology. (1998) [Pubmed]
  31. Aneurysms of anomalous splenomesenteric trunk: clinical features and surgical management in two cases. Settembrini, P.G., Jausseran, J.M., Roveri, S., Ferdani, M., Carmo, M., Rudondy, P., Serra, M.G., Pezzuoli, G. J. Vasc. Surg. (1996) [Pubmed]
  32. A prospective pilot study of extended (D3) and superextended para-aortic lymphadenectomy (D4) in patients with T3 or T4 gastric cancer managed by total gastrectomy. Maeta, M., Yamashiro, H., Saito, H., Katano, K., Kondo, A., Tsujitani, S., Ikeguchi, M., Kaibara, N. Surgery (1999) [Pubmed]
  33. Injection of microspheres into pancreatic arteries causes acute hemorrhagic pancreatitis in the rat: a new animal model. Redha, F., Uhlschmid, G., Ammann, R.W., Freiburghaus, A.U. Pancreas (1990) [Pubmed]
  34. Distribution of blood-borne particles of two different sizes in rat spleens. Satodate, R., Suzuki, A., Iwasaki, T., Sasou, S. Virchows Arch., B, Cell Pathol. (1986) [Pubmed]
  35. Cytoreductive surgery combined with intraoperative chemo-hyperthermia and postoperative radiotherapy in the management of advanced pancreatic adenocarcinoma: feasibility aspects and efficacy. Kouloulias, V.E., Nikita, K.S., Kouvaris, J.R., Uzunoglu, N.K., Golematis, V.C., Papavasiliou, C.G., Vlahos, L.J. Journal of hepato-biliary-pancreatic surgery. (2001) [Pubmed]
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