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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Alkylation of urinary guanine in mice by the organophosphorus insecticide tetrachlorvinphos.

The methylating capability of tetrachlorvinphos on urinary guanine in mice has been investigated using an insecticide labeled at both O-CH3 groups. Following intraperitoneal administration of the 14C-labeled insecticide to mice, about 0.57% of the radioactivity in the O- to 24-hr samples was associated with the purine fraction. The amount of [7-14C]methylguanine in 0- to 48-hr urine samples, estimated as fraction of applied dose, was 26-31 X 10(-5). The results obtained indicate possible chemical alkylation of urinary guanine. On the other hand, a considerable portion of radioactivity is probably incorporated via the C-1 pool.[1]


  1. Alkylation of urinary guanine in mice by the organophosphorus insecticide tetrachlorvinphos. Zayed, S.M., Mostafa, I.Y., Hegazi, B. Ecotoxicol. Environ. Saf. (1984) [Pubmed]
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