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Chemical Compound Review

Debantic     1,2,4-trichloro-5-[(E)-2- chloro-1...

Synonyms: Gardcide, Stirofox, Stitifos, Vinfos, Appex, ...
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Disease relevance of Gardona

  • The different routes of treatment with gardona caused toxicity of marrow indicated as significant increases in the percentage of polychromatic erythrocytes over that of the control [1].
  • Non-genotoxic effects were not detected in vitro either in the Salmonella/microsome assay nor in the SOS chromotest when bacterial tester strains were exposed to atrazine, molinate, chlorpyrifosmethyl and tetrachlorvinphos in the absence or presence of S9 mix [2].
  • Tetrachlorvinphos was added to the mineral mixture of medicated cattle (n = 13) at the rate of 1.6 mg/day/kg of body weight for a 29-week period beginning May 2, 1975 [3].

High impact information on Gardona


Chemical compound and disease context of Gardona


Biological context of Gardona

  • Residues of stirofos (rabon) in eggs of laying hens treated for northern fowl mite control by dipping [9].
  • An aqueous saturated solution of tetrachlorvinphos affected neither mitosis (after seed-soak and root treatment) nor meiosis (after spraying the plants at the flowering stage) [10].
  • The effect of the organophosphorus insecticide tetrachlorvinphos (Gardona) has been studied on the mitosis and meiosis of Vicia faba, using the pure insecticide [10].
  • Alkylation of urinary guanine in mice by the organophosphorus insecticide tetrachlorvinphos [11].
  • Simultaneous reconstitution of Na+/H+ antiport and (H+ + K+)-ATPase could explain why reconstituted ATPase appeared less cation-specific than the native enzyme (Rabon, E.C., Gunther, R.B., Soumarmon, A., Bassilian, B., Lewin, M.J.M. and Sachs, G. (1985) J. Biol. Chem. 260, 10200-10212) [12].

Anatomical context of Gardona


Associations of Gardona with other chemical compounds


Gene context of Gardona


Analytical, diagnostic and therapeutic context of Gardona


  1. Cytogenetic effects of pesticides. II. Induction of micronuclei in mouse bone marrow by the insecticide gardona. Amer, S.M., Fahmy, M.A. Mutat. Res. (1983) [Pubmed]
  2. Genotoxicity of six pesticides by Salmonella mutagenicity test and SOS chromotest. Ruiz, M.J., Marzin, D. Mutat. Res. (1997) [Pubmed]
  3. Tetrachlorvinphos as an ineffective feed additive in control of gastrointestinal nematodes of beef cattle. Noblet, G.P. Am. J. Vet. Res. (1978) [Pubmed]
  4. Cytogenetic effects of pesticides. IV. Cytogenetic effects of the insecticides Gardona and Dursban. Amer, S.M., Aly, F.A. Mutat. Res. (1992) [Pubmed]
  5. Microbial mutation studies with tetrachlorvinphos (Gardona)). Brooks, T.M., Dean, B.J., Hutson, D.H., Potter, D. Mutat. Res. (1982) [Pubmed]
  6. Enzyme induction by repeated adminstration of tetrachlorvinphos in rats. Moroi, K., Ushiyama, S., Satoh, T., Kuga, T. Toxicol. Appl. Pharmacol. (1976) [Pubmed]
  7. Cytotoxic effects and induction of cytochromes P450 1A1/2 by insecticides, in hepatic or epidermal cells: binding capability to the Ah receptor. Delescluse, C., Ledirac, N., de Sousa, G., Pralavorio, M., Lesca, P., Rahmani, R. Toxicol. Lett. (1998) [Pubmed]
  8. Resistance to cyfluthrin and tetrachlorvinphos in the lesser mealworm, Alphitobius diaperinus, collected from the eastern United States. Hamm, R.L., Kaufman, P.E., Reasor, C.A., Rutz, D.A., Scott, J.G. Pest Manag. Sci. (2006) [Pubmed]
  9. Residues of stirofos (rabon) in eggs of laying hens treated for northern fowl mite control by dipping. Ivey, M.C., Devaney, J.A., Ivie, G.W., Beerwinkle, K.R. Poult. Sci. (1982) [Pubmed]
  10. Cytological effects of the insecticide tetrachlorvinphos. Amer, S.M., Mikhael, E. Toxicol. Lett. (1983) [Pubmed]
  11. Alkylation of urinary guanine in mice by the organophosphorus insecticide tetrachlorvinphos. Zayed, S.M., Mostafa, I.Y., Hegazi, B. Ecotoxicol. Environ. Saf. (1984) [Pubmed]
  12. H+ transport by reconstituted gastric (H+ + K+)-ATPase. Skrabanja, A.T., Asty, P., Soumarmon, A., Joep, J., de Pont, H.H., Lewin, M.J. Biochim. Biophys. Acta (1986) [Pubmed]
  13. Abnormal in vitro development of ovarian follicles explanted from mice exposed to tetrachlorvinphos. Nayudu, P.L., Kiesel, P.S., Nowshari, M.A., Hodges, J.K. Reprod. Toxicol. (1994) [Pubmed]
  14. Comparative evaluation of four registered acaricides for field control of northern fowl mites on caged laying hens. Hall, R.D., Vandepopuliere, J.M., English, L.M., Jaynes, W., Lyons, J.J., Doisy, K.E., Foehse, M.C. Poult. Sci. (1980) [Pubmed]
  15. Comparisons of permethrin formulations and application methods for northern fowl mite control on caged laying hens. Arthur, F.H., Axtell, R.C. Poult. Sci. (1982) [Pubmed]
  16. Monitoring insecticide resistance in house flies (Diptera: Muscidae) from New York dairies. Kaufman, P.E., Scott, J.G., Rutz, D.A. Pest Manag. Sci. (2001) [Pubmed]
  17. Biochemical genetics of altered acetylcholinesterase resistance to insecticides in the house fly. Plapp, F.W., Tripathi, R.K. Biochem. Genet. (1978) [Pubmed]
  18. In vitro inhibition of blood cholinesterase activities from horse, cow, and rat by tetrachlorvinphos. Karanth, S., Pope, C. International journal of toxicology. (2003) [Pubmed]
  19. Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro. Vinggaard, A.M., Hnida, C., Breinholt, V., Larsen, J.C. Toxicology in vitro : an international journal published in association with BIBRA. (2000) [Pubmed]
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