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Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi.

Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide-linked enzymes (alpha-hydroxyacid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.[1]

References

  1. Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi. Montamat, E.E., Burgos, C., Gerez de Burgos, N.M., Rovai, L.E., Blanco, A., Segura, E.L. Science (1982) [Pubmed]
 
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