Selective potentiation of hyperthermic killing of hypoxic cells by 5-thio-D-glucose.
The modification of cell lethality at elevated temperatures by 5-thio-D-glucose, the nearest analog of D-glucose was studied with the use of HeLa cells in the presence or absence of oxygen. When the cells were exposed to temperatures ranging from 40.5-42 degrees for 0.5 to 4 hr in the presence of 5-thio-D-glucose (5 mM), there was a selective potentiation of hyperthermic killing of hypoxic cells. No enhanced killing of oxic cells by 5-thio-D-glucose was seen at these temperatures. These results indicate that glucose metabolism may be involved in influencing the heat sensitivity of hypoxic cells. The low toxicity of 5-thio-D-glucose and its specificity to hypoxic cells suggest that it may be a useful adjuvant to hyperthermic therapy.[1]References
- Selective potentiation of hyperthermic killing of hypoxic cells by 5-thio-D-glucose. Kim, S.H., Kim, J.H., Hahn, E.W. Cancer Res. (1978) [Pubmed]
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