Disease relevance of D-Glucose, 5-thio-

• This specific toxicity suggested that 5-thio-D-glucose may be a useful adjuvant to radiotherapy by eliminating hypoxic protection [1].
• 5-Thio-D-glucose effectively killed hypoxic mastocytoma cells of DBA/2J mice, whereas it merely suppressed the growth of oxic cells [1].
• This study examined the effects of one agent, 5-thio-D-glucose (5TG) on renal hypertrophy and transforming growth factor beta1 (TGF-beta1) [2].
• Potentiation of cytotoxicity of 5-thio-D-glucose on hypoxic cells by hyperthermia [3].
• For the present study, 5-thio-D-glucose and cis-platin were chosen for evaluation in an ocular system because they exhibit antitumour activity, and interaction with radiation, particularly in hypoxia [4].

High impact information on D-Glucose, 5-thio-

• To investigate the mechanisms by which heat affects cancer cells, we used 5-thio-D-glucose, an inhibitor of glycolysis in HeLa S-3 cells, under aerobic and hypoxic conditions at temperatures ranging from 37 degrees to 43 degrees C. Drug alone or heat alone killed a minimum number of cells under aerobic or hypoxic conditions [5].
• Since we have previously reported that several male antifertility agents including 5-thio-D-glucose and lonidamine demonstrate hyperthermic sensitizing effects in HeLa cells, we wished to determine whether gossypol also exhibits the hyperthermic sensitization [6].
• Membranes of mammary gland. XV. 5-Thio-D-glucose decreases lactose content and inhibits secretory vesicle maturation in lactating rat mammary gland [7].
• Biodistribution and pharmacokinetics of S-35-labeled 5-thio-D-glucose in hamsters bearing pancreatic tumors [8].
• The effect of 5-thio-D-glucose (5-TG) on the hexosemonophosphate shunt (HMS) and on aerobic glycolysis was studied in the mouse small intestine [9].

Chemical compound and disease context of D-Glucose, 5-thio-

• A potent inhibitor of D-glucose transport across the membrane, 5-thio-D-glucose (5-TDG) was examined with respect to its effect on runway and maze performance as well as on food and water intakes and body weight [10].
• Pretreatment with 5-thio-D-glucose (5-T-G) failed to prevent ALX diabetes, administration of zinc sulfate (Zn(2+))-enriched drinking water, however, reduced ALX-induced hyperglycemia [11].
• The combined effects of hyperthermia and uncouplers of oxidative phosphorylation (dinitrophenol (DNP) or m-chlorocarbonylcyanide phenyl-hydrazone (CCCP) or 5-thio-d-glucose (5-TG) on mammalian cell survival were studied in vitro [12].

Biological context of D-Glucose, 5-thio-

• Failure of 5-thio-D-glucose to alter cell survival in irradiated or unirradiated EMT6 tumors [13].
• Dominant lethal gene test of 5-thio-D-glucose in male mice [14].
• Cytogenetic studies in bone marrow cells and dividing spermatocytes I in male mice and the sex-linked recessive lethal gene test in Drosophila melanogaster were initiated to evaluate the mutagenic potential of 5-thio-D-glucose, a reversible male contraceptive in some mammals [15].
• Metabolic effects of 5-thio-D-glucose [16].
• Tissue distribution and retention of 5-thio-D-glucose in animal tumor models [17].

Anatomical context of D-Glucose, 5-thio-

• The modification of cell lethality at elevated temperatures by 5-thio-D-glucose, the nearest analog of D-glucose was studied with the use of HeLa cells in the presence or absence of oxygen [18].
• Cell specific action of 5-thio-D-glucose in mouse testis [19].
• Effect of 5-thio-D-glucose on insulin receptors of liver cell membranes [20].

Associations of D-Glucose, 5-thio- with other chemical compounds

• Comparison of the cytotoxicity of 5-thio-D-glucose and misonidazole on hypoxic cells in vitro [21].
• The pulse-injection indicator-dilution technique in vivo has been used to study the interaction of 5-thio-D-glucose and methyl-beta-D-thiogalactopyranoside with renal tubular surfaces in dog kidney [22].
• Cell survival in V79 multicell spheroids treated with dehydroascorbate, 5-thio-D-glucose and 2-deoxy-D-glucose [23].

Gene context of D-Glucose, 5-thio-

• Effect of 5-thio-D-glucose on protein synthesis in vitro by various types of cells from rat testes [24].
• These data show that both single-dose and 3-week treatment with 5-thio-D-glucose produced a hyperinsulinemic diabetes in male albino mice [25].

Analytical, diagnostic and therapeutic context of D-Glucose, 5-thio-

• Intraperitoneal injection of A/J mice with 1.5 g/kg of 5-thio-D-glucose 2 hr prior to X irradiation of the foot reduced early foot skin damage through Day 40 postirradiation by a dose modification factor of 1.3 +/- 0 [26].
• When preincubating islet cultures with either D-G or its chemically closely related analogue 5-thio-D-glucose (5-T-G), different effects were obtained after treatment with either ALX or STZ [27].

References