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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Diflunisal disposition and hypouricemic response in osteoarthritis.

The disposition of diflunisal was studied at daily doses of 250, 500, 750, 1000 mg/day in 24 male patients (mean age 65 yr and mean creatinine clearance 72 ml/min). Each dose was given for 14 days and diflunisal apparent oral clearance and serum urate was measured on the last day of each dosing regimen. There was a dose-dependent decrease in mean diflunisal apparent oral clearance with dose from 628 ml/hr at 250 mg/day to 426 ml/hr at 1000 mg/day, with most of the decrease occurring at the lower doses and becoming less pronounced at doses of 750 and 1000 mg/day. There was a strong positive correlation between diflunisal apparent oral clearance and creatinine clearance. Diflunisal induced a hypouricemic effect at all doses, but the responses at doses of 750 and 1000 mg/day did not differ.[1]


  1. Diflunisal disposition and hypouricemic response in osteoarthritis. Meffin, P.J., Brooks, P.M., Bertouch, J., Veenendaal, J.R., Harrington, B.J. Clin. Pharmacol. Ther. (1983) [Pubmed]
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