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Stolinsky, D.C. et al.

Rotational therapy with a colchicine analog in chronic granulocytic leukemia.

9 patients with chronic granulocytic leukemia were treated sequentially with busulfan, 6-mercaptopurine, and trimethylcolchicinic acid methyl ether d-tartrate (TMCA; NSC-36354). Smoothness of control of the disease was similar with busulfan and 6-mercaptopurine, but it was significantly poorer with TMCA. Toxic effects of therapy and median survival were similar to those observed with conventional therapy.[1]

References

Rotational therapy with a colchicine analog in chronic granulocytic leukemia. Stolinsky, D.C., Weiner, J.M., Bateman, J.R. Oncology (1980) [Pubmed]

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