The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound

Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

[search][options]

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Riccardi, A. et al.

Cytokinetic changes in the peripheral blood of leukemic patients during cytostatic therapy. V. Effect of VP 16 213 studied with flow cytofluorometry and cytoautoradiography.

The cytokinetic effects induced by VP 16 213 (50-60 mg/sqm/12 hrs for 10 doses) on the peripheral blood and bone marrow blasts of two patients with acute myelomonocytic leukemia have been studied using DNA flow cytofluorometry and in vitro tritiated thymidine cytoautoradiography. Besides a striking cytocidal effect, the drug induced cell synchronization in the G2 phase of the cell cycle as evidenced by the building up of tetraploid nuclei without an increase in mitotic figures. The synchronizing effect was greater in the bone marrow than in peripheral blood. In one patient, the removal of the G2 block was observed which paralleled an increase in proliferative activity. The usefulness of flow cytofluorometry for rapidly detecting the cytokinetic changes induced in acute leukemia blasts by cytostatic drugs is affirmed.[1]

References

Cytokinetic changes in the peripheral blood of leukemic patients during cytostatic therapy. V. Effect of VP 16 213 studied with flow cytofluorometry and cytoautoradiography. Riccardi, A., Montecucco, C.M., Mazzini, G., Cresci, R., Traversi, E. Basic and applied histochemistry. (1980) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg