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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Chlorambucil therapy in hairy cell leukemia: effects on lipid composition and lymphocyte subpopulations.

Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil. Both had an objective hematologic response as determined by a return to normal hematocrit and platelet count. This was also reflected in the mononuclear cell fraction by the normalization of cholesterol content, cholesterol/phospholipid ratio, and the lymphocyte subpopulations. This article confirms previous reports on the efficacy of chlorambucil in this setting and describes some morphological, and biochemical concomitant events.[1]


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