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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Polarity of amber mutations in ribosomal protein genes of Escherichia coli.

Two amber mutations have been mapped inside the spcA-strA region (now called rpsE-rpsL) on the bacterial genome. Derivatives of the transducing phage lambda fus3 carrying each mutation were constructed and assayed in ultraviolet-irradiated bacteria to identify the mutated genes and measure the polarity of the mutations. The data indicated that both mutations, 3162(Am) and 3161(Am), affect genes coding for ribosomal proteins: rplC (L3) and rpsN (S14), respectively. It was shown also that each mutation exerts, inside of its respective operon (S10 and spc units), a relatively strong polar effect on genes distal to the mutated locus.[1]


  1. Polarity of amber mutations in ribosomal protein genes of Escherichia coli. Cabezón, T., Delcuve, G., Faelen, M., Desmet, L., Bollen, A. J. Bacteriol. (1980) [Pubmed]
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