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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Detection of mutagenicity of procarbazine by the host-mediated assay with polychlorinated biphenyl (aroclor 1254) as enzyme inducer.

Procarbazine [N-isoppropyl-alpha-(2-methylhydrazino)-p-toluamide] was tested for mutagenicity with Salmonella typhimurium G46 in the host-mediated assay by using male BALB/c mice pretreated orally with polychlorinated biphenyl ( PCB, Aroclor 1254). Procarbazine was weakly mutagenic without PCB pretreatment, but the pretreatment greatly enhanced the mutagenicity of this compound. The administration of 500 mg PCB/kg 1 day before procarbazine dosage was suitable for the detection of the mutagenicity. Among PCB, 3-methylcholanthrene (3-MC) and phenobarbital sodium (PB), the former 2 inducers showed much stronger enhancing effects than PB. The pretreatment with 3-MC in combination with PB did not cause further enhancement compared with 3-MC alone.[1]

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