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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Hepatitis B viral markers in severe viral hepatitis: influence of steroid therapy.

In our double-blind randomized trial of methylprednisolone vs. placebo in severe viral hepatitis, 16 patients with hepatitis B (8 on steroid, 8 on placebo) were followed for at least 4 weeks. Four of the eight patients receiving methylprednisolone eventually died and all patients on placebo survived. Despite marked reduction in serum IgG in steroid-treated patients, the decline in HBsAg titer and disappearance of Dane particle markers was the same in both treatment groups. A nonspecific depression of anti-HBc was noted in patients given steroid. There is no evidence that corticosteroid therapy accelerates viral replication when the acute hepatitis is severe.[1]

References

  1. Hepatitis B viral markers in severe viral hepatitis: influence of steroid therapy. Greenberg, H.B., Robinson, W.S., Knauer, C.M., Gregory, P.B. Hepatology (1981) [Pubmed]
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