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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Hepatitis B Virus

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Disease relevance of Hepatitis B Virus

  • Three of them had consistently elevated levels of circulating Dane-particle markers, including Dane-particle-associated DNA polymerase activity, hepatitis B core antigen and Dane-particle-associated DNA [1].

High impact information on Hepatitis B Virus

  • Parenteral interferon administration at a dosage between 6.0 X 10(3) and 17 X 10(4) U per kilogram per day was associated with a rapid and reproducible fall in all Dane-particle markers in the three patients [1].
  • Association of e antigen with Dane particle DNA in sera from asymptomatic carriers of hepatitis B surface antigen [2].
  • During the 2-year follow-up period, HBsAg remained present in all patients, but the Dane particle markers HBeAg and DNA polymerase disappeared in two of 10 patients who had received interferon, and in 4 of 10 patients from the placebo group [3].
  • Despite marked reduction in serum IgG in steroid-treated patients, the decline in HBsAg titer and disappearance of Dane particle markers was the same in both treatment groups [4].
  • The cores of Dane particles (hepatitis B core antigen; HBCAg) were prepared by treating the Dane particle preparation with mercaptoethanol and Nonidet P-40 [5].

Chemical compound and disease context of Hepatitis B Virus


Gene context of Hepatitis B Virus

  • DNA was extracted from 26 of these sera and assayed for its ability to anneal to a [32P]-DNA probe that is a copy of Dane particle DNA [2].
  • Radioactive DNA was prepared in extensive (4 h) Dane particle DNA polymerase reactions [10].
  • In contrast, e antigen-negative patients had an average DNA polymerase activity of 40+/-6.9 cpm (P less than 0.1) and an average Dane particle count equal to 0.6% of the HBS Ag [11].
  • The HBeAg polypeptides (P15.5/16.5) derived from sera were physicochemically different from the two polypeptides with HBeAg activity (P19 and P45) liberated from Dane particle cores by the conventional method involving incubation with Nonidet P40 and 2-mercaptoethanol [12].
  • 109 biopsy samples from 35 HBAg serologically positive and 74 negative patients were examined by IFL for the presence of the surface and core antigenic determinants associated with the Dane particle [13].

Analytical, diagnostic and therapeutic context of Hepatitis B Virus


  1. Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. Greenberg, H.B., Pollard, R.B., Lutwick, L.I., Gregory, P.B., Robinson, W.S., Merigan, T.C. N. Engl. J. Med. (1976) [Pubmed]
  2. Association of e antigen with Dane particle DNA in sera from asymptomatic carriers of hepatitis B surface antigen. Werner, B.G., O'Connell, A.P., Summers, J. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  3. Spontaneous disappearance of viral replication and liver cell inflammation in HBsAg-positive chronic active hepatitis: results of a placebo vs. interferon trial. Schalm, S.W., Heijtink, R.A. Hepatology (1982) [Pubmed]
  4. Hepatitis B viral markers in severe viral hepatitis: influence of steroid therapy. Greenberg, H.B., Robinson, W.S., Knauer, C.M., Gregory, P.B. Hepatology (1981) [Pubmed]
  5. Large-scale isolation of Dane particles from plasma containing hepatitis B antigen and deomnstration of circular double-stranded DNA molecule extruding directly from their cores. Takahashi, T., Nakagawa, S., Hashimoto, T., Takahashi, K., Imai, M. J. Immunol. (1976) [Pubmed]
  6. Full and empty particles of hepatitis B virus in hepatocytes from patients with HBsAg-positive chronic active hepatitis. Sakamoto, Y., Yamada, G., Mizuno, M., Nishihara, T., Kinoyama, S., Kobayashi, T., Takahashi, T., Nagashima, H. Lab. Invest. (1983) [Pubmed]
  7. Inhibition of hepatitis-B-virus DNA polymerase by phosphonoformate: studies on its mode of action. Hess, G., Arnold, W., Meyer zum Büschenfelde, K.H. J. Med. Virol. (1980) [Pubmed]
  8. Preparation of a dane core (hepatitis B) antigen from human plasma. Fauvel, M., Babiuk, L., Sheaff, E.T., Spence, L. Can. J. Microbiol. (1975) [Pubmed]
  9. Inhibition of hepatitis B Dane particle DNA polymerase activity by pyrophosphate analogs. Nordenfelt, E., Oberg, B., Helgstrand, E., Miller, E. Acta pathologica et microbiologica Scandinavica. Section B, Microbiology. (1980) [Pubmed]
  10. DNA synthesized in the hepatitis B Dane particle DNA polymerase reaction. Lutwick, L.I., Robinson, W.S. J. Virol. (1977) [Pubmed]
  11. Correlation of e antigen, DNA polymerase activity, and Dane particles in chronic benign and chronic active type B hepatitis infections. Tong, M.J., Stevenson, D., Gordon, I. J. Infect. Dis. (1977) [Pubmed]
  12. Hepatitis B e antigen polypeptides isolated from sera of individuals infected with hepatitis B virus: comparison with HBeAg polypeptide derived from Dane particles. Takahashi, K., Imai, M., Gotanda, T., Sano, T., Oinuma, A., Mishiro, S., Miyakawa, Y., Mayumi, M. J. Gen. Virol. (1980) [Pubmed]
  13. Intrahepatic localization of the surface (HBsAg) and core (HBcAg) antigenic determinants associated with hepatitis B virus in biopsy samples from patients with liver disease. Rizzetto, M., Crivelli, O., Verme, G., Suriani, R. La Ricerca in clinica e in laboratorio. (1976) [Pubmed]
  14. Early diagnosis of Hepatitis B by Dane particle associated DNA polymerase assay. Cappel, R., De Cuyper, F., Van Beers, D., Toppet, M., Cadranel, S. J. Gen. Virol. (1977) [Pubmed]
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