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Chemical Compound Review

AGN-PC-00HRH8     11,17-dihydroxy-17-(2- hydroxyethanoyl)-6...

Synonyms: SureCN541256, AC1L1HJP, STL372918, AR-1C0360, HMS3086J15, ...
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Disease relevance of methylprednisolone


Psychiatry related information on methylprednisolone


High impact information on methylprednisolone


Chemical compound and disease context of methylprednisolone


Biological context of methylprednisolone


Anatomical context of methylprednisolone


Associations of methylprednisolone with other chemical compounds


Gene context of methylprednisolone


Analytical, diagnostic and therapeutic context of methylprednisolone

  • Subjective and spirometric indexes of the severity of the asthma were similar on entry into the study in all patients, but only 9 of 48 patients (19 percent) treated with methylprednisolone required hospital admission, as compared with 23 of 49 patients (47 percent) in the control group (P less than 0.003) [36].
  • The patients were randomly assigned in double-blind fashion to receive an intravenous infusion of either saline placebo or high-dose methylprednisolone (15 mg per kilogram of body weight, to a maximum of 1000 mg) on their admission to the hospital and again 24 hours later [37].
  • A controlled trial of methylprednisolone in the emergency treatment of acute asthma [36].
  • At the six-month evaluation, the patients treated with methylprednisolone reported more improvement, less pain on the visual-analogue scale, and less physical disability [38].
  • Using intravital fluorescence microscopy, we observed PMN aggregation and embolization in the mesenteric vessels of rats given intra-arterial infusions of ZAP; this was also prevented by pretreatment with 30 mg/kg MP [39].


  1. High-dose corticosteroids in patients with the adult respiratory distress syndrome. Bernard, G.R., Luce, J.M., Sprung, C.L., Rinaldo, J.E., Tate, R.M., Sibbald, W.J., Kariman, K., Higgins, S., Bradley, R., Metz, C.A. N. Engl. J. Med. (1987) [Pubmed]
  2. Methylprednisolone plus chlorambucil as compared with methylprednisolone alone for the treatment of idiopathic membranous nephropathy. The Italian Idiopathic Membranous Nephropathy Treatment Study Group. Ponticelli, C., Zucchelli, P., Passerini, P., Cesana, B. N. Engl. J. Med. (1992) [Pubmed]
  3. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group. Beck, R.W., Cleary, P.A., Anderson, M.M., Keltner, J.L., Shults, W.T., Kaufman, D.I., Buckley, E.G., Corbett, J.J., Kupersmith, M.J., Miller, N.R. N. Engl. J. Med. (1992) [Pubmed]
  4. The effects of high-dose corticosteroids in patients with septic shock. A prospective, controlled study. Sprung, C.L., Caralis, P.V., Marcial, E.H., Pierce, M., Gelbard, M.A., Long, W.M., Duncan, R.C., Tendler, M.D., Karpf, M. N. Engl. J. Med. (1984) [Pubmed]
  5. Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis. A randomized, controlled trial. Gourley, M.F., Austin, H.A., Scott, D., Yarboro, C.H., Vaughan, E.M., Muir, J., Boumpas, D.T., Klippel, J.H., Balow, J.E., Steinberg, A.D. Ann. Intern. Med. (1996) [Pubmed]
  6. Electrocardiographic precordial mapping in anterior myocardial infarction. The critical period for interventions as exemplified by methylprednisolone. Selwyn, A.P., Fox, K.M., Welman, E., Jonathan, A., Shillingford, J.P. Circulation (1978) [Pubmed]
  7. Growth, pulmonary, and endocrine function in chronic asthma patients on daily and alternate-day adrenocorticosteroid therapy. Shapiro, G.G., Tattoni, D.S., Kelley, V.C., Pierson, W.E., Bierman, C.W. J. Allergy Clin. Immunol. (1976) [Pubmed]
  8. Injection of steroids and local anaesthetics as therapy for low-back pain. Sonne, M., Christensen, K., Hansen, S.E., Jensen, E.M. Scand. J. Rheumatol. (1985) [Pubmed]
  9. Systemic corticosteroid therapy for acute asthma exacerbations. Fiel, S.B., Vincken, W. The Journal of asthma : official journal of the Association for the Care of Asthma. (2006) [Pubmed]
  10. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Olbrich, H., Fliegauf, M., Hoefele, J., Kispert, A., Otto, E., Volz, A., Wolf, M.T., Sasmaz, G., Trauer, U., Reinhardt, R., Sudbrak, R., Antignac, C., Gretz, N., Walz, G., Schermer, B., Benzing, T., Hildebrandt, F., Omran, H. Nat. Genet. (2003) [Pubmed]
  11. Intrathecal methylprednisolone for postherpetic neuralgia. Zetlaoui, P.J., Cosserat, J. N. Engl. J. Med. (2001) [Pubmed]
  12. Intrathecal methylprednisolone for intractable postherpetic neuralgia. Kotani, N., Kushikata, T., Hashimoto, H., Kimura, F., Muraoka, M., Yodono, M., Asai, M., Matsuki, A. N. Engl. J. Med. (2000) [Pubmed]
  13. Successful hand transplantation. One-year follow-up. Louisville Hand Transplant Team. Jones, J.W., Gruber, S.A., Barker, J.H., Breidenbach, W.C. N. Engl. J. Med. (2000) [Pubmed]
  14. Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus. Carette, S., Leclaire, R., Marcoux, S., Morin, F., Blaise, G.A., St-Pierre, A., Truchon, R., Parent, F., Levésque, J., Bergeron, V., Montminy, P., Blanchette, C. N. Engl. J. Med. (1997) [Pubmed]
  15. Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. The German Aplastic Anemia Study Group. Frickhofen, N., Kaltwasser, J.P., Schrezenmeier, H., Raghavachar, A., Vogt, H.G., Herrmann, F., Freund, M., Meusers, P., Salama, A., Heimpel, H. N. Engl. J. Med. (1991) [Pubmed]
  16. Controlled trial of methylprednisolone and chlorambucil in idiopathic membranous nephropathy. Ponticelli, C., Zucchelli, P., Imbasciati, E., Cagnoli, L., Pozzi, C., Passerini, P., Grassi, C., Limido, D., Pasquali, S., Volpini, T. N. Engl. J. Med. (1984) [Pubmed]
  17. Troleandomycin and methylprednisolone for treatment of the hypereosinophilic syndrome. Edwards, D., Wald, J.A., Dobozin, B.S., Kirkpatrick, C.H. N. Engl. J. Med. (1987) [Pubmed]
  18. Chronic glucocorticoid therapy amplifies glomerular injury in rats with renal ablation. Garcia, D.L., Rennke, H.G., Brenner, B.M., Anderson, S. J. Clin. Invest. (1987) [Pubmed]
  19. Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis. Boumpas, D.T., Austin, H.A., Vaughn, E.M., Klippel, J.H., Steinberg, A.D., Yarboro, C.H., Balow, J.E. Lancet (1992) [Pubmed]
  20. Thymocyte apoptosis induced by p53-dependent and independent pathways. Clarke, A.R., Purdie, C.A., Harrison, D.J., Morris, R.G., Bird, C.C., Hooper, M.L., Wyllie, A.H. Nature (1993) [Pubmed]
  21. Corticosteroids block binding of chemotactic peptide to its receptor on granulocytes and cause disaggregation of granulocyte aggregates in vitro. Skubitz, K.M., Craddock, P.R., Hammerschmidt, D.E., August, J.T. J. Clin. Invest. (1981) [Pubmed]
  22. Methylprednisolone prevention of increased lung vascular permeability following endotoxemia in sheep. Brigham, K.L., Bowers, R.E., McKeen, C.R. J. Clin. Invest. (1981) [Pubmed]
  23. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. Bracken, M.B., Shepard, M.J., Collins, W.F., Holford, T.R., Young, W., Baskin, D.S., Eisenberg, H.M., Flamm, E., Leo-Summers, L., Maroon, J. N. Engl. J. Med. (1990) [Pubmed]
  24. Interaction of lactoferrin, monocytes, and T lymphocyte subsets in the regulation of steady-state granulopoiesis in vitro. Bagby, G.C., Rigas, V.D., Bennett, R.M., Vandenbark, A.A., Garewal, H.S. J. Clin. Invest. (1981) [Pubmed]
  25. The mechanism of action of a single dose of methylprednisolone on acute inflammation in vivo. Wiener, S.L., Wiener, R., Urivetzky, M., Shafer, S., Isenberg, H.D., Janov, C., Meilman, E. J. Clin. Invest. (1975) [Pubmed]
  26. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. Bracken, M.B., Shepard, M.J., Holford, T.R., Leo-Summers, L., Aldrich, E.F., Fazl, M., Fehlings, M., Herr, D.L., Hitchon, P.W., Marshall, L.F., Nockels, R.P., Pascale, V., Perot, P.L., Piepmeier, J., Sonntag, V.K., Wagner, F., Wilberger, J.E., Winn, H.R., Young, W. JAMA (1997) [Pubmed]
  27. Regulation of alveolar macrophage transforming growth factor-beta secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat. Khalil, N., Whitman, C., Zuo, L., Danielpour, D., Greenberg, A. J. Clin. Invest. (1993) [Pubmed]
  28. Development of a standard treatment protocol for severe acute respiratory syndrome. So, L.K., Lau, A.C., Yam, L.Y., Cheung, T.M., Poon, E., Yung, R.W., Yuen, K.Y. Lancet (2003) [Pubmed]
  29. Combination therapy with pulse cyclophosphamide plus pulse methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis. Illei, G.G., Austin, H.A., Crane, M., Collins, L., Gourley, M.F., Yarboro, C.H., Vaughan, E.M., Kuroiwa, T., Danning, C.L., Steinberg, A.D., Klippel, J.H., Balow, J.E., Boumpas, D.T. Ann. Intern. Med. (2001) [Pubmed]
  30. Early administration of corticosteroids in emergency room treatment of acute asthma. Stein, L.M., Cole, R.P. Ann. Intern. Med. (1990) [Pubmed]
  31. An increase in myeloid-related protein serum levels precedes acute renal allograft rejection. Burkhardt, K., Radespiel-Tröger, M., Rupprecht, H.D., Goppelt-Struebe, M., Riess, R., Renders, L., Hauser, I.A., Kunzendorf, U. J. Am. Soc. Nephrol. (2001) [Pubmed]
  32. Modulation of glomerular endothelin and endothelin receptor gene expression in aminonucleoside-induced nephrosis. Nakamura, T., Ebihara, I., Fukui, M., Osada, S., Tomino, Y., Masaki, T., Goto, K., Furuichi, Y., Koide, H. J. Am. Soc. Nephrol. (1995) [Pubmed]
  33. Cyclosporin A inhibition of macrophage colony-stimulating factor (M-CSF) production by activated human T lymphocytes. Frétier, S., Besse, A., Delwail, A., Garcia, M., Morel, F., Leprivey-Lorgeot, V., Wijdenes, J., Praloran, V., Lecron, J.C. J. Leukoc. Biol. (2002) [Pubmed]
  34. Adhesion molecules in multiple sclerosis: relation to subtypes of disease and methylprednisolone therapy. Elovaara, I., Ukkonen, M., Leppäkynnäs, M., Lehtimäki, T., Luomala, M., Peltola, J., Dastidar, P. Arch. Neurol. (2000) [Pubmed]
  35. Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: implications for tolerance induction. Smiley, S.T., Csizmadia, V., Gao, W., Turka, L.A., Hancock, W.W. Transplantation (2000) [Pubmed]
  36. A controlled trial of methylprednisolone in the emergency treatment of acute asthma. Littenberg, B., Gluck, E.H. N. Engl. J. Med. (1986) [Pubmed]
  37. High-dose intravenous methylprednisolone therapy for pain in children and adolescents with sickle cell disease. Griffin, T.C., McIntire, D., Buchanan, G.R. N. Engl. J. Med. (1994) [Pubmed]
  38. A controlled trial of corticosteroid injections into facet joints for chronic low back pain. Carette, S., Marcoux, S., Truchon, R., Grondin, C., Gagnon, J., Allard, Y., Latulippe, M. N. Engl. J. Med. (1991) [Pubmed]
  39. Corticosteroids inhibit complement-induced granulocyte aggregation. A possible mechanism for their efficacy in shock states. Hammerschmidt, D.E., White, J.G., Craddock, P.R., Jacob, H.S. J. Clin. Invest. (1979) [Pubmed]
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