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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Scheutwinkel-Reich, M. et al.

Investigation of the butyrophenone tranquilizer azaperone and its main metabolites with the Salmonella/microsome test.

In previous experiments, azaperone was found to be weakly mutagenic, after metabolic activation, in the Ames assay. In this study, we subjected metabolites found in rat and swine to the Salmonella/microsome test. 5 histidine-auxotrophic strains were used. The main metabolites could be classified as weakly mutagenic substances.[1]

References

Investigation of the butyrophenone tranquilizer azaperone and its main metabolites with the Salmonella/microsome test. Scheutwinkel-Reich, M., Preiss, A.M., Fülle, I., Grohmann, H.G., Stan, H.J. Mutat. Res. (1982) [Pubmed]

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