The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Stresnil     1-(4-fluorophenyl)-4-(4- pyridin-2...

Synonyms: Azaperon, Eucalmyl, Azaperona, Azaperone, Azeperone, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of R-1929


Psychiatry related information on R-1929


High impact information on R-1929


Chemical compound and disease context of R-1929


Biological context of R-1929

  • 3 Azaperone did not modify plasma protein concentration but venous blood packed cell volume and haemoglobin concentration were reduced by 5 to 10% for at least 4 hours [10].
  • In previous experiments, azaperone was found to be weakly mutagenic, after metabolic activation, in the Ames assay [12].
  • Fifteen minutes after administration of azaperone, systemic arterial pressure was reduced by 35% as a result of a 45% increase in systemic vascular conductance and 10% decrease in cardiac output (Q) [13].
  • Urine samples collected from a horse after intramuscular administration of 40 mg of azaperone were extracted at pH 10 before and after acid hydrolysis [14].
  • Treatment with azaperone was not related to farrowing environment, piglet weight or litter size [15].

Anatomical context of R-1929


Associations of R-1929 with other chemical compounds


Analytical, diagnostic and therapeutic context of R-1929


  1. Occupational (photo)allergic contact dermatitis from azaperone in a piglet dealer. Brasch, J., Hessler, H.J., Christophers, E. Contact Derm. (1991) [Pubmed]
  2. Influence of infused beta-adrenergic agonists on porcine blood metabolites and catecholamines. Mersmann, H.J. J. Anim. Sci. (1989) [Pubmed]
  3. A behavioral pharmacological study of mafoprazine, a new phenylpiperazine derivative. Yamamura, M., Nakagawa, H., Kinoshita, K., Ochiai, T., Ishida, R. Jpn. J. Pharmacol. (1988) [Pubmed]
  4. Paradoxical excitement following the intravenous administration of azaperone in the horse. Dodman, N.H., Waterman, A.E. Equine Vet. J. (1979) [Pubmed]
  5. Mutagenicity evaluation of azaperone in the Salmonella/microsome test. Duverger-van Bogaert, M., Vanparys, P., de Meester, C., Marsboom, R. Drug and chemical toxicology. (1987) [Pubmed]
  6. The effects of azaperone, a sedative neuroleptic of the butyrophenone series, on dominant-subordinate behaviour in wistar rats competing for food. Desmedt, L.K., Van Bruggen, J.A., Niemegeers, C.J. Psychopharmacologia. (1975) [Pubmed]
  7. Distinguishing a benzodiazepine agonist (triazolam) from a nonagonist anxiolytic (buspirone) by electroencephalography: kinetic-dynamic studies. Greenblatt, D.J., Harmatz, J.S., Gouthro, T.A., Locke, J., Shader, R.I. Clin. Pharmacol. Ther. (1994) [Pubmed]
  8. 4-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine. Wappler, F., Scholz, J., Fiege, M., Kolodzie, K., Kudlik, C., Weisshorn, R., Schulte am Esch, J. Anesthesiology (1999) [Pubmed]
  9. Open-field behaviour in sheep following treatment with the neuroleptics azaperone and acetylpromazine. Hughes, R.N., Syme, L.A., Syme, G.J. Psychopharmacology (Berl.) (1977) [Pubmed]
  10. Effects of azaperone on cardiovascular and respiratory functions in the horse. Lees, P., Serrano, L. Br. J. Pharmacol. (1976) [Pubmed]
  11. Clinical effects of azaperone-metomidate, as compared to propionylpromazine-xylazine-metomidate or xylazine-ketamine combinations in anaesthesia of dogs. Mgasa, M.N., Sagenge, E. Zentralblatt für Veterinärmedizin. Reihe A. (1989) [Pubmed]
  12. Investigation of the butyrophenone tranquilizer azaperone and its main metabolites with the Salmonella/microsome test. Scheutwinkel-Reich, M., Preiss, A.M., Fülle, I., Grohmann, H.G., Stan, H.J. Mutat. Res. (1982) [Pubmed]
  13. Redistribution of cardiac output caused by opening of arteriovenous anastomoses by a combination of azaperone and metomidate. van Woerkens, L.J., Duncker, D.J., Huigen, R.J., van der Giessen, W.J., Verdouw, P.D. British journal of anaesthesia. (1990) [Pubmed]
  14. Investigation of the metabolism of azaperone in the horse. Chui, Y.C., Esaw, B., Laviolette, B. J. Chromatogr. (1994) [Pubmed]
  15. Investigation of the relationship between farrowing environment, sex steroid concentrations and maternal aggression in gilts. McLean, K.A., Lawrence, A.B., Petherick, J.C., Deans, L., Chirnside, J., Vaughan, A., Nielsen, B.L., Webb, R. Anim. Reprod. Sci. (1998) [Pubmed]
  16. Identification of metabolites of azaperone in horse urine. Sams, R.A., Gerken, D.F., Detra, R.L., Stanley, S.D., Wood, W.E., Tobin, T., Yang, J.M., Tai, H.H., Jegananthan, A., Watt, D.S. Journal of pharmaceutical sciences. (1996) [Pubmed]
  17. Effect of muscle injection site and drug temperature on pre-anaesthetic sedation in pigs. Clutton, R.E., Bracken, J., Ritchie, M. Vet. Rec. (1998) [Pubmed]
  18. Effect of azaperone on cardiovascular responsiveness in stress-sensitive pigs. Gregory, N.G., Wilkins, L.J. J. Vet. Pharmacol. Ther. (1986) [Pubmed]
  19. Identification and quantitation of 1-arylpiperazines, metabolites resulting from side-chain cleavage of (4-substituted aryl-1-piperazinyl)alkyl heterocyclic derivatives in rat plasma and brain. Caccia, S., Notarnicola, A., Fong, M.H., Benfenati, E. J. Chromatogr. (1984) [Pubmed]
  20. Development of a rapid screening test for veterinary sedatives and the beta-blocker carazolol in porcine kidney by ELISA. Cooper, J., Delahaut, P., Fodey, T.L., Elliott, C.T. The Analyst. (2004) [Pubmed]
  21. The suppression of electro-ejaculation in the chacma baboon (Papio ursinus) by azaperone. Meltzer, D.G., van Vuuren, M., Bornman, M.S. Journal of the South African Veterinary Association. (1988) [Pubmed]
  22. Provision of anaesthesia for porcine cardiac transplantation at the veterinary school in Trinidad and Tobago. Merritt-Charles, L., Chen, D., Legall, C., Mootoo, N., Brann, S.H., Perrault, L., Williams, D., Thomas, C.N., Ezeokoli, C. The West Indian medical journal. (2003) [Pubmed]
  23. Standing laparoscopic-guided uterine biopsy in a southern white rhinoceros (Ceratotherium simum simum). Radcliffe, R.M., Hendrickson, D.A., Richardson, G.L., Zuba, J.R., Radcliffe, R.W. J. Zoo Wildl. Med. (2000) [Pubmed]
  24. Butorphanol and azaperone as a safe alternative for repeated chemical restraint in captive white rhinoceros (Ceratotherium simum). Radcliffe, R.W., Ferrell, S.T., Childs, S.E. J. Zoo Wildl. Med. (2000) [Pubmed]
  25. Determination of residues of azaperone in the kidneys by liquid chromatography with fluorescence detection. Cerkvenik-Flajs, V. Anal. Chim. Acta (2007) [Pubmed]
  26. Combined azaperone and metomidate anaesthesia in liver transplantation in the pig. Biver, A., Jacquet, N., Moor, M.C., Lamy, M. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (1976) [Pubmed]
WikiGenes - Universities