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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Psychological functioning of bipolar manic-depressives in remission.

Several dimensions of psychological functioning of bipolar manic-depressives in remission were investigated. The following hypotheses were examined: (1) During remission, these individuals exhibit psychological maladjustment or a lack of positive mental health. (2) Bipolar manic-depressives are characterized by strong external orientations. The Personal Orientation Inventory, Marlowe-Crowne Social Desirability Scale, Levenson's Internal and Powerful Others Locus of Control Scales, and the Embedded Figures Test were administered to matched groups of 35 bipolar manic-depressives and 35 normal comparison subjects. Discriminant analysis disclosed no significant differences between the two groups on measures of positive mental health and on measures of external orientation. The relationship between these results and the etiology and treatment of manic-depressive disorder is briefly discussed, as well as the contradiction these findings pose to current views of this disorder pervasive among professional and lay populations.[1]


  1. Psychological functioning of bipolar manic-depressives in remission. MacVane, J.R., Lange, J.D., Brown, W.A., Zayat, M. Arch. Gen. Psychiatry (1978) [Pubmed]
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