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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Nonimmunological production of leukotrienes induced by platelet-activating factor.

Platelet-activating factor caused rapid pulmonary vasoconstriction and edema in isolated lungs perfused with albumin-free salt solution devoid of formed blood elements. These effects may be due in part to the action of leukotrienes D4 and C4, which were identified by bioassay and high-pressure liquid chromatography in the lung effluent after stimulation by platelet-activating factor. These findings help illuminate some of the deleterious effects that platelet-activating factor elicits in anaphylactic reactions and possibly in other forms of lung injury.[1]


  1. Nonimmunological production of leukotrienes induced by platelet-activating factor. Voelkel, N.F., Worthen, S., Reeves, J.T., Henson, P.M., Murphy, R.C. Science (1982) [Pubmed]
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