The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Theophylline metabolism in premature infants.

The theophylline metabolite pattern in premature infants was studied with gas chromatography-mass spectrometry. The identities of metabolites were established by retention time indices and mass chromatograms. In the steady state of a multiple-dose regimen, the urinary metabolites of theophylline identified and quantified were caffeine (9.6 plus or minus 4.8%), theophylline (50.4 plus or minus 6.7%), 3-methylxanthine (1.3 plus or minus 0.7%), 1,3-dimethyluric acid (27.7% plus or minus 8.8%), and 1-methyluric acid (9.3 plus or minus 5.4%). Those in plasma were caffeine (21.4 plus or minus 6.1%), theophylline (73.6 plus or minus 6.5%), 3-methylxanthine (0.7 plus or minus 0.4%), 1,3-dimethyluric acid (2.6 plus or minus 1.2%), and 1-methyluric acid (0.6 plus or minus 0.3%). Occasionally, theobromine, the metabolic breakdown product of caffeine, was found in urine and plasma in small quantities. The demethylation pathway occurring predominantly in adults was substituted by N-methylation to caffeine in premature infants; the other major metabolic pathway of theophylline in adults, C-8 oxidation to 1,3-dimethyluric acid, was slightly diminished. We concluded that the enzyme systems responsible for the C-8 oxidation of theophylline are relatively active in premature infants and that the development of the enzyme systems responsible for oxidative demethylation of theophylline lags behind. The oxidation and demethylation pathways of theophylline in premature infants are significant.[1]


  1. Theophylline metabolism in premature infants. Tserng, K.Y., King, K.C., Takieddine, F.N. Clin. Pharmacol. Ther. (1981) [Pubmed]
WikiGenes - Universities