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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pregnancy in the Turner syndrome with only 45,X chromosomal constitution.

A 31-year-old white female, 127 cm tall and with other findings of the Turner syndrome, had had normal menses and had become pregnant at ages 23 and 26 years. Chromosomal analyses of several tissues, including both ovaries, revealed only 45,X karyotypes. Both of her daughters had 46,XX karyotypes in lymphocytes. This patient and nine other reported cases of fertile, apparently nonmosaic 45,X women illustrate an extreme of ovarian function in the Turner syndrome and raise questions about the absolute need for XX oocytes in ovarian development. The possibility of pregnancy must be considered in all patients with Turner syndrome, a relatively common chromosomal disorder.[1]


  1. Pregnancy in the Turner syndrome with only 45,X chromosomal constitution. Wray, H.L., Freeman, M.V., Ming, P.M. Fertil. Steril. (1981) [Pubmed]
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