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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Early effects of inhaled Ca-DTPA on the rat lung.

Inhalation of calcium trisodium diethylenetriaminepentaacetate (Ca-DTPA) increases the removal of plutonium and other transuranics from the body. Data are required to determine possible biological effects from inhaled DTPA. Female rats were given a single or 12 daily, 2-4 h, inhalation exposures to aerosols of 10, 20 and 40% Ca-DTPA and the lungs were examined at 21 and 42 days following the last exposure. No pulmonary pathology was found from the single inhalation treatment with Ca-DTPA while only a slight, peripheral, histiocytosis was observed in the lungs of multiple-treated rats. There was no significant effect of DTPA treatments on body weight, lung weight, hematology or serum chemistry values.[1]


  1. Early effects of inhaled Ca-DTPA on the rat lung. Smith, V.H., Dagle, G.E., Gelman, R.A., Ragan, H.A. Toxicol. Lett. (1980) [Pubmed]
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