The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Pentaind     2-[2-[2-(bis(carboxymethyl) amino)ethyl...

Synonyms: Detapac, Penthanil, Pentetates, DTPA, CaNa-DTPA, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Detapac

 

Psychiatry related information on Detapac

 

High impact information on Detapac

  • Administration of DTPA iron (III) did not alter mean systemic arterial pressure, but did protect baboons in the presence of high levels of TNF-alpha and free radical overproduction [1].
  • In contrast, reagents which are excluded from the cell such as superoxide dismutase or DTPA did not protect the cells against H2O2 [9].
  • Applying a three-compartment model of inulin/DTPA kinetics (which takes backleak into account) revealed the residence time of intravenously administered inulin/DTPA in the compartment occupied by tubular fluid and urine to be markedly prolonged, 20 vs. 6 min in controls, suggesting reduced velocity of tubular fluid flow [10].
  • Technetium sulfur colloid was found to bind more firmly to cooked egg whites than did the water soluble marker DTPA [11].
  • Gastric emptying was measured using a gamma camera technique and a solid meal labeled with 99mtechnetium-labeled diethylenetriaminepentaacetic acid [12].
 

Chemical compound and disease context of Detapac

 

Biological context of Detapac

  • The DTPA-based, insoluble, inactive contrast agent was internalized into dendritic cells by phagocytosis [18].
  • In nine normal nonsmoking adults, the rate of clearance of DTPA, corrected for background activity, was 1.5 (SD 0.7) %/min over the first 10 min after inhalation [19].
  • Second, in the presence of DTPA, which inhibits H2O2-induced SOD1 non-active site fragmentation, (bi)carbonate scavenged the enzyme-bound oxidant at the SOD1 active site to produce the carbonate radical anion, CO3*-, thus protecting against active site SOD1 fragmentation [20].
  • RESEARCH DESIGN AND METHODS--From the records of the Children's Hospital Diabetes Clinic, we selected 70 patients with GFR determined by 99mTc-labeled DTPA plasma clearance, stable renal function, and simultaneous measurements of height, weight, blood pressure, HbA1c, and plasma creatinine [21].
  • The initial distribution volume of AIB and MeAIB in brain tissue was several-fold greater than that of DTPA and the tissue plasma volume, and this difference was not accounted for by red blood cell uptake [22].
 

Anatomical context of Detapac

 

Associations of Detapac with other chemical compounds

 

Gene context of Detapac

 

Analytical, diagnostic and therapeutic context of Detapac

  • The half-life of DTPA iron (III) was 51 +/- 9 min in normal baboons; primary clearance was consistent with glomerular filtration [1].
  • The 111In-labeled pentetic acid (DTPA), derivative of mAb 225 (111In-DTPA-225) was injected intraperitoneally into nude mice bearing subcutaneous tumor xenografts [38].
  • T1 relaxation time at 90 MHz, measured in tumors removed from nude mice 24 hr after injection of Gd X DTPA-mAb 19-9 (Gd, 20 mumol/kg; 16 DTPA molecules per mAb molecule), was significantly decreased (by 15%) as compared with the control group [2].
  • Immediately following the therapeutic infusion, diethylenetriaminepentaacetic acid was administered by continuous i.v. infusion over 3 days at 250 mg/m2 body surface area/24 h [39].
  • In animals receiving 90Y-CO17-1A prepared by the cyclic DTPA anhydride technique, tumor volume was unchanged from base line at a dose of 200 microCi/25 g [40].

References

  1. Efficacy of treatment with the iron (III) complex of diethylenetriamine pentaacetic acid in mice and primates inoculated with live lethal dose 100 Escherichia coli. Molina, L., Studenberg, S., Wolberg, G., Kazmierski, W., Wilson, J., Tadepalli, A., Chang, A.C., Kosanke, S., Hinshaw, L. J. Clin. Invest. (1996) [Pubmed]
  2. Selective modification of NMR relaxation time in human colorectal carcinoma by using gadolinium-diethylenetriaminepentaacetic acid conjugated with monoclonal antibody 19-9. Curtet, C., Tellier, C., Bohy, J., Conti, M.L., Saccavini, J.C., Thedrez, P., Douillard, J.Y., Chatal, J.F., Koprowski, H. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. Myocardial capillary permeability after regional ischemia and reperfusion in the in vivo canine heart. Effect of superoxide dismutase. Svendsen, J.H., Bjerrum, P.J., Haunsø, S. Circ. Res. (1991) [Pubmed]
  4. L-asparaginase pharmacokinetics and asparagine levels in cerebrospinal fluid of rhesus monkeys and humans. Riccardi, R., Holcenberg, J.S., Glaubiger, D.L., Wood, J.H., Poplack, D.G. Cancer Res. (1981) [Pubmed]
  5. Scintigraphic detection of metastatic melanoma using indium 111/DTPA conjugated anti-gp240 antibody (ZME-018). Kirkwood, J.M., Neumann, R.D., Zoghbi, S.S., Ernstoff, M.S., Cornelius, E.A., Shaw, C., Ziyadeh, T., Fine, J.A., Unger, M.W. J. Clin. Oncol. (1987) [Pubmed]
  6. Potential 166Ho radiopharmaceuticals for endovascular radionuclide therapy. II. Preparation and evaluation of 166Ho-DTPA. Majali, M.A., Saxena, S.K., Joshi, S.H., Unni, P.R., Ramamoorthy, N. Nuclear medicine communications. (2001) [Pubmed]
  7. Current imaging and possible therapeutic management of glucagonoma tumors: a case report. Johnson, D.S., Coel, M.N., Bornemann, M. Clinical nuclear medicine. (2000) [Pubmed]
  8. Technetium-99m labeled micro aerosol "Pertechnegas". A new agent for ventilation imaging in suspected pulmonary emboli. Ashburn, W.L., Belezzuoli, E.V., Dillon, W.A., Mensh, B.D., Hoogland, D., Yeung, D.W., Coade, G.E. Clinical nuclear medicine. (1993) [Pubmed]
  9. Nitroxide stable radicals protect beating cardiomyocytes against oxidative damage. Samuni, A., Winkelsberg, D., Pinson, A., Hahn, S.M., Mitchell, J.B., Russo, A. J. Clin. Invest. (1991) [Pubmed]
  10. Pathophysiology of protracted acute renal failure in man. Moran, S.M., Myers, B.D. J. Clin. Invest. (1985) [Pubmed]
  11. Effect of water and fat on gastric emptying of solid meals. Kroop, H.S., Long, W.B., Alavi, A., Hansell, J.R. Gastroenterology (1979) [Pubmed]
  12. Effect of metoclopramide in chronic gastric retention after gastric surgery. Metzger, W.H., Cano, R., Sturdevant, R.A. Gastroenterology (1976) [Pubmed]
  13. Pretargeting of renal cell carcinoma: improved tumor targeting with a bivalent chelate. Boerman, O.C., Kranenborg, M.H., Oosterwijk, E., Griffiths, G.L., McBride, W.J., Oyen, W.J., de Weijert, M., Oosterwijk-Wakka, J., Hansen, H.J., Corstens, F.H. Cancer Res. (1999) [Pubmed]
  14. Magnetic resonance imaging and miniarthroscopy of metacarpophalangeal joints: sensitive detection of morphologic changes in rheumatoid arthritis. Ostendorf, B., Peters, R., Dann, P., Becker, A., Scherer, A., Wedekind, F., Friemann, J., Schulitz, K.P., Mödder, U., Schneider, M. Arthritis Rheum. (2001) [Pubmed]
  15. Diagnostic usefulness of renal scanning after angiotensin converting enzyme inhibitors. Davidson, R., Wilcox, C.S. Hypertension (1991) [Pubmed]
  16. Localization of technetium-99m DTPA in neurofibroma. Siddiqui, A.R. J. Nucl. Med. (1986) [Pubmed]
  17. Enalaprilat-enhanced renography in a rat model of renovascular hypertension. Kopecky, R.T., McAfee, J.G., Thomas, F.D., Anderson, G.H., Hellwig, B., Roskopf, M., Patchin, D. J. Nucl. Med. (1990) [Pubmed]
  18. A responsive MRI contrast agent to monitor functional cell status. Himmelreich, U., Aime, S., Hieronymus, T., Justicia, C., Uggeri, F., Zenke, M., Hoehn, M. Neuroimage (2006) [Pubmed]
  19. The effect of inhalation of platelet-activating factor on the pulmonary clearance of 99mTc-DTPA aerosol. Mason, G.R., Peters, A.M., Myers, M.J., Ind, P.W., Hughes, J.M. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  20. Mechanism of hydrogen peroxide-induced Cu,Zn-superoxide dismutase-centered radical formation as explored by immuno-spin trapping: the role of copper- and carbonate radical anion-mediated oxidations. Ramirez, D.C., Gomez Mejiba, S.E., Mason, R.P. Free Radic. Biol. Med. (2005) [Pubmed]
  21. Serum creatinine, height, and weight do not predict glomerular filtration rate in children with IDDM. Waz, W.R., Quattrin, T., Feld, L.G. Diabetes Care (1993) [Pubmed]
  22. Transport of alpha-aminoisobutyric acid across brain capillary and cellular membranes. Blasberg, R.G., Fenstermacher, J.D., Patlak, C.S. J. Cereb. Blood Flow Metab. (1983) [Pubmed]
  23. 99mTc-labeled nucleotides as tumor-seeking radiodiagnostic agents. Elmaleh, D.R., Zamecnik, P.C., Castronovo, F.P., Strauss, H.W., Rapaport, E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  24. Selective T-cell ablation with bismuth-213-labeled anti-TCRalphabeta as nonmyeloablative conditioning for allogeneic canine marrow transplantation. Bethge, W.A., Wilbur, D.S., Storb, R., Hamlin, D.K., Santos, E.B., Brechbiel, M.W., Fisher, D.R., Sandmaier, B.M. Blood (2003) [Pubmed]
  25. Multiple sclerosis disease activity correlates with gadolinium-enhanced magnetic resonance imaging. Gonzalez-Scarano, F., Grossman, R.I., Galetta, S., Atlas, S.W., Silberberg, D.H. Ann. Neurol. (1987) [Pubmed]
  26. Enhanced biliary iron excretion with amphiphilic diethylenetriaminepentaacetic acid. Adams, P.C., Lin, E., Barber, K.R., Grant, C.W. Hepatology (1991) [Pubmed]
  27. Stimulated human neutrophils limit iron-catalyzed hydroxyl radical formation as detected by spin-trapping techniques. Britigan, B.E., Rosen, G.M., Thompson, B.Y., Chai, Y., Cohen, M.S. J. Biol. Chem. (1986) [Pubmed]
  28. Detection of renovascular hypertension. State of the art: 1992. Mann, S.J., Pickering, T.G. Ann. Intern. Med. (1992) [Pubmed]
  29. Bismuth-212-labeled anti-Tac monoclonal antibody: alpha-particle-emitting radionuclides as modalities for radioimmunotherapy. Kozak, R.W., Atcher, R.W., Gansow, O.A., Friedman, A.M., Hines, J.J., Waldmann, T.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  30. Involved-field radiotherapy and intra-Ommaya methotrexate/cytarabine in patients with AIDS-related lymphomatous meningitis. Chamberlain, M.C., Dirr, L. J. Clin. Oncol. (1993) [Pubmed]
  31. Effect of external negative pressure on pulmonary 99mTc-DTPA clearance in humans. Suzuki, Y., Kanazawa, M., Fujishima, S., Ishizaka, A., Kubo, A. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  32. Radioimmunotherapy of small cell lung carcinoma with the two-step method using a bispecific anti-carcinoembryonic antigen/anti-diethylenetriaminepentaacetic acid (DTPA) antibody and iodine-131 Di-DTPA hapten: results of a phase I/II trial. Vuillez, J.P., Kraeber-Bodéré, F., Moro, D., Bardiès, M., Douillard, J.Y., Gautherot, E., Rouvier, E., Barbet, J., Garban, F., Moreau, P., Chatal, J.F. Clin. Cancer Res. (1999) [Pubmed]
  33. Preclinical comparison of (111)In-labeled DTPA- or DOTA-bombesin analogs for receptor-targeted scintigraphy and radionuclide therapy. Breeman, W.A., de Jong, M., Erion, J.L., Bugaj, J.E., Srinivasan, A., Bernard, B.F., Kwekkeboom, D.J., Visser, T.J., Krenning, E.P. J. Nucl. Med. (2002) [Pubmed]
  34. Preclinical comparison in AR4-2J tumor-bearing mice of four radiolabeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-somatostatin analogs for tumor diagnosis and internal radiotherapy. Froidevaux, S., Heppeler, A., Eberle, A.N., Meier, A.M., Häusler, M., Beglinger, C., Béhé, M., Powell, P., Mäcke, H.R. Endocrinology (2000) [Pubmed]
  35. A kit formulated under good manufacturing practices for labeling human epidermal growth factor with 111In for radiotherapeutic applications. Reilly, R.M., Scollard, D.A., Wang, J., Mondal, H., Chen, P., Henderson, L.A., Bowen, B.M., Vallis, K.A. J. Nucl. Med. (2004) [Pubmed]
  36. Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors. Achilefu, S., Srinivasan, A., Schmidt, M.A., Jimenez, H.N., Bugaj, J.E., Erion, J.L. J. Med. Chem. (2003) [Pubmed]
  37. Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo. Reubi, J.C., Waser, B., Schaer, J.C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M.A., Bugaj, J.E. European journal of nuclear medicine. (1998) [Pubmed]
  38. Imaging of human tumor xenografts with an indium-111-labeled anti-epidermal growth factor receptor monoclonal antibody. Goldenberg, A., Masui, H., Divgi, C., Kamrath, H., Pentlow, K., Mendelsohn, J. J. Natl. Cancer Inst. (1989) [Pubmed]
  39. Initial experience evaluating 90yttrium-radiolabeled anti-carcinoembryonic antigen chimeric T84.66 in a phase I radioimmunotherapy trial. Wong, J.Y., Williams, L.E., Yamauchi, D.M., Odom-Maryon, T., Esteban, J.M., Neumaier, M., Wu, A.M., Johnson, D.K., Primus, F.J., Shively, J.E. Cancer Res. (1995) [Pubmed]
  40. Radioimmunotherapy of human colorectal carcinoma xenografts using 90Y-labeled monoclonal antibody CO17-1A prepared by two bifunctional chelate techniques. Lee, Y.C., Washburn, L.C., Sun, T.T., Byrd, B.L., Crook, J.E., Holloway, E.C., Steplewski, Z. Cancer Res. (1990) [Pubmed]
 
WikiGenes - Universities