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Chemical Compound Review

Pentaind     2-[2-[2-(bis(carboxymethyl) amino)ethyl...

Synonyms: Detapac, Penthanil, Pentetates, DTPA, CaNa-DTPA, ...
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Disease relevance of Detapac


Psychiatry related information on Detapac


High impact information on Detapac

  • Administration of DTPA iron (III) did not alter mean systemic arterial pressure, but did protect baboons in the presence of high levels of TNF-alpha and free radical overproduction [1].
  • In contrast, reagents which are excluded from the cell such as superoxide dismutase or DTPA did not protect the cells against H2O2 [9].
  • Applying a three-compartment model of inulin/DTPA kinetics (which takes backleak into account) revealed the residence time of intravenously administered inulin/DTPA in the compartment occupied by tubular fluid and urine to be markedly prolonged, 20 vs. 6 min in controls, suggesting reduced velocity of tubular fluid flow [10].
  • Technetium sulfur colloid was found to bind more firmly to cooked egg whites than did the water soluble marker DTPA [11].
  • Gastric emptying was measured using a gamma camera technique and a solid meal labeled with 99mtechnetium-labeled diethylenetriaminepentaacetic acid [12].

Chemical compound and disease context of Detapac


Biological context of Detapac

  • The DTPA-based, insoluble, inactive contrast agent was internalized into dendritic cells by phagocytosis [18].
  • In nine normal nonsmoking adults, the rate of clearance of DTPA, corrected for background activity, was 1.5 (SD 0.7) %/min over the first 10 min after inhalation [19].
  • Second, in the presence of DTPA, which inhibits H2O2-induced SOD1 non-active site fragmentation, (bi)carbonate scavenged the enzyme-bound oxidant at the SOD1 active site to produce the carbonate radical anion, CO3*-, thus protecting against active site SOD1 fragmentation [20].
  • RESEARCH DESIGN AND METHODS--From the records of the Children's Hospital Diabetes Clinic, we selected 70 patients with GFR determined by 99mTc-labeled DTPA plasma clearance, stable renal function, and simultaneous measurements of height, weight, blood pressure, HbA1c, and plasma creatinine [21].
  • The initial distribution volume of AIB and MeAIB in brain tissue was several-fold greater than that of DTPA and the tissue plasma volume, and this difference was not accounted for by red blood cell uptake [22].

Anatomical context of Detapac


Associations of Detapac with other chemical compounds


Gene context of Detapac


Analytical, diagnostic and therapeutic context of Detapac

  • The half-life of DTPA iron (III) was 51 +/- 9 min in normal baboons; primary clearance was consistent with glomerular filtration [1].
  • The 111In-labeled pentetic acid (DTPA), derivative of mAb 225 (111In-DTPA-225) was injected intraperitoneally into nude mice bearing subcutaneous tumor xenografts [38].
  • T1 relaxation time at 90 MHz, measured in tumors removed from nude mice 24 hr after injection of Gd X DTPA-mAb 19-9 (Gd, 20 mumol/kg; 16 DTPA molecules per mAb molecule), was significantly decreased (by 15%) as compared with the control group [2].
  • Immediately following the therapeutic infusion, diethylenetriaminepentaacetic acid was administered by continuous i.v. infusion over 3 days at 250 mg/m2 body surface area/24 h [39].
  • In animals receiving 90Y-CO17-1A prepared by the cyclic DTPA anhydride technique, tumor volume was unchanged from base line at a dose of 200 microCi/25 g [40].


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  14. Magnetic resonance imaging and miniarthroscopy of metacarpophalangeal joints: sensitive detection of morphologic changes in rheumatoid arthritis. Ostendorf, B., Peters, R., Dann, P., Becker, A., Scherer, A., Wedekind, F., Friemann, J., Schulitz, K.P., Mödder, U., Schneider, M. Arthritis Rheum. (2001) [Pubmed]
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  17. Enalaprilat-enhanced renography in a rat model of renovascular hypertension. Kopecky, R.T., McAfee, J.G., Thomas, F.D., Anderson, G.H., Hellwig, B., Roskopf, M., Patchin, D. J. Nucl. Med. (1990) [Pubmed]
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  19. The effect of inhalation of platelet-activating factor on the pulmonary clearance of 99mTc-DTPA aerosol. Mason, G.R., Peters, A.M., Myers, M.J., Ind, P.W., Hughes, J.M. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  20. Mechanism of hydrogen peroxide-induced Cu,Zn-superoxide dismutase-centered radical formation as explored by immuno-spin trapping: the role of copper- and carbonate radical anion-mediated oxidations. Ramirez, D.C., Gomez Mejiba, S.E., Mason, R.P. Free Radic. Biol. Med. (2005) [Pubmed]
  21. Serum creatinine, height, and weight do not predict glomerular filtration rate in children with IDDM. Waz, W.R., Quattrin, T., Feld, L.G. Diabetes Care (1993) [Pubmed]
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  26. Enhanced biliary iron excretion with amphiphilic diethylenetriaminepentaacetic acid. Adams, P.C., Lin, E., Barber, K.R., Grant, C.W. Hepatology (1991) [Pubmed]
  27. Stimulated human neutrophils limit iron-catalyzed hydroxyl radical formation as detected by spin-trapping techniques. Britigan, B.E., Rosen, G.M., Thompson, B.Y., Chai, Y., Cohen, M.S. J. Biol. Chem. (1986) [Pubmed]
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