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MeSH Review


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Disease relevance of Histiocytosis


High impact information on Histiocytosis


Chemical compound and disease context of Histiocytosis


Biological context of Histiocytosis


Anatomical context of Histiocytosis

  • Because Langerhans cells (LC) in peripheral tissues are generally "immature" cells with poor lymphostimulatory activity, the contribution of immune responses initiated by LC to the pathogenesis of pulmonary LC histiocytosis (LCH) has been uncertain [17].
  • In contrast, expression of constitutively activated H-Ras in bone-marrow cells resulted in the in vitro growth, in the absence of exogenous factors, of colonies that contained only macrophages and of lines of cells resembling dendritic cells, and, upon in vivo injection of the transduced cells, a fatal histiocytosis/monocytic leukemia [18].
  • The diagnosis of histiocytosis X may be established by identifying the Langerhans histiocyte, characterized by nuclear grooves, immunoreactivity for S-100 protein, and pentalamellar cytoplasmic structures seen by electron microscopy [19].
  • Prior to incubation with the WI-38 cell line, the cell supernatant then was preincubated with nonpreserved anti-human PDGF (AA- and BB-chain) resulting in an 80% decrease of tritiated thymidine uptake and procollagen-III-peptide production in the group of histiocytosis X patients compared with native supernatants [20].
  • Macrophages in reactive proliferation, histiocytosis X, and neoplastic proliferation gave positive reaction for IAP [21].

Gene context of Histiocytosis


Analytical, diagnostic and therapeutic context of Histiocytosis


  1. Histiocytosis X. Purified (T6+) cells from bone granuloma produce interleukin 1 and prostaglandin E2 in culture. Arenzana-Seisdedos, F., Barbey, S., Virelizier, J.L., Kornprobst, M., Nezelof, C. J. Clin. Invest. (1986) [Pubmed]
  2. Autozygosity mapping, to chromosome 11q25, of a rare autosomal recessive syndrome causing histiocytosis, joint contractures, and sensorineural deafness. Moynihan, L.M., Bundey, S.E., Heath, D., Jones, E.L., McHale, D.P., Mueller, R.F., Markham, A.F., Lench, N.J. Am. J. Hum. Genet. (1998) [Pubmed]
  3. Flow-cytometric DNA content of histiocytosis X (Langerhans cell histiocytosis). Rabkin, M.S., Wittwer, C.T., Kjeldsberg, C.R., Piepkorn, M.W. Am. J. Pathol. (1988) [Pubmed]
  4. Thickened pituitary stalk on magnetic resonance imaging in children with central diabetes insipidus. Leger, J., Velasquez, A., Garel, C., Hassan, M., Czernichow, P. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  5. Applications of electron microscopy to diagnostic pulmonary pathology. Wang, N.S. Hum. Pathol. (1983) [Pubmed]
  6. More on pamidronate in Langerhans'-cell histiocytosis. Egeler, R.M. N. Engl. J. Med. (2001) [Pubmed]
  7. Successful treatment of Langerhans'-cell histiocytosis with etanercept. Henter, J.I., Karlén, J., Calming, U., Bernstrand, C., Andersson, U., Fadeel, B. N. Engl. J. Med. (2001) [Pubmed]
  8. Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative disease. Willman, C.L., Busque, L., Griffith, B.B., Favara, B.E., McClain, K.L., Duncan, M.H., Gilliland, D.G. N. Engl. J. Med. (1994) [Pubmed]
  9. 2-Chlorodeoxyadenosine to treat refractory histiocytosis X. Saven, A., Figueroa, M.L., Piro, L.D., Rosenblatt, J.D. N. Engl. J. Med. (1993) [Pubmed]
  10. Amiodarone lung toxicity: a human and experimental study. Costa-Jussà, F.R., Corrin, B., Jacobs, J.M. J. Pathol. (1984) [Pubmed]
  11. Ig surface receptors and erythrophagocytic activity of histiocytosis X cells in vitro. Nezelof, C., Diebold, N., Rousseau-Merck, M.F. J. Pathol. (1977) [Pubmed]
  12. Letter: Technetium-99m-sulfur colloid lung scan in patients with histiocytosis X. Bowen, B.M., Coates, G., Garnett, E.S. J. Nucl. Med. (1975) [Pubmed]
  13. 111In-pentetreotide scintigraphy in patients with Langerhans' cell histiocytosis. Weinmann, P., Crestani, B., Tazi, A., Genereau, T., Mal, H., Aubier, M., Valeyre, D., Moretti, J.L., Le Guludec, D., Lebtahi, R. J. Nucl. Med. (2000) [Pubmed]
  14. Clofazimine-induced crystal-storing histiocytosis producing chronic abdominal pain in a leprosy patient. Sukpanichnant, S., Hargrove, N.S., Kachintorn, U., Manatsathit, S., Chanchairujira, T., Siritanaratkul, N., Akaraviputh, T., Thakerngpol, K. Am. J. Surg. Pathol. (2000) [Pubmed]
  15. Early effects of inhaled Ca-DTPA on the rat lung. Smith, V.H., Dagle, G.E., Gelman, R.A., Ragan, H.A. Toxicol. Lett. (1980) [Pubmed]
  16. Primary eosinophilic granuloma of frontal lobe. Diagnostic use of S-100 protein. Moscinski, L.C., Kleinschmidt-DeMasters, B.K. Cancer (1985) [Pubmed]
  17. Evidence that Langerhans cells in adult pulmonary Langerhans cell histiocytosis are mature dendritic cells: importance of the cytokine microenvironment. Tazi, A., Moreau, J., Bergeron, A., Dominique, S., Hance, A.J., Soler, P. J. Immunol. (1999) [Pubmed]
  18. Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras. Guo, X., Schrader, K.A., Xu, Y., Schrader, J.W. Oncogene (2005) [Pubmed]
  19. Histiocytosis X of the vulva: a case report and review of the literature. Otis, C.N., Fischer, R.A., Johnson, N., Kelleher, J.F., Powell, J.L. Obstetrics and gynecology. (1990) [Pubmed]
  20. Modulation of fibroblast activity in histiocytosis X by platelet-derived growth factor. Uebelhoer, M., Bewig, B., Kreipe, H., Nowak, D., Magnussen, H., Barth, J. Chest (1995) [Pubmed]
  21. Immunohistochemical determination of immunosuppressive acidic protein in reactive and neoplastic diseases of macrophage. Aozasa, K., Ueda, T., Ayata, M., Tsujimoto, M., Fujita, M.Q., Yamamura, T., Tsujimura, T. Cancer (1987) [Pubmed]
  22. Canine cutaneous histiocytoma is an epidermotropic Langerhans cell histiocytosis that expresses CD1 and specific beta 2-integrin molecules. Moore, P.F., Schrenzel, M.D., Affolter, V.K., Olivry, T., Naydan, D. Am. J. Pathol. (1996) [Pubmed]
  23. Histologic and immunohistochemical study comparing xanthoma disseminatum and histiocytosis X. Zelger, B., Cerio, R., Orchard, G., Fritsch, P., Wilson-Jones, E. Archives of dermatology. (1992) [Pubmed]
  24. Immunohistochemical detection of granulocyte/macrophage colony-stimulating factor in Langerhans' cell histiocytosis. Emile, J.F., Peuchmaur, M., Fraitag, S., Bodemer, C., Brousse, N. Histopathology (1993) [Pubmed]
  25. Erdheim-Chester disease with prominent pericardial involvement: clinical, radiologic, and histologic findings. Gupta, A., Kelly, B., McGuigan, J.E. Am. J. Med. Sci. (2002) [Pubmed]
  26. Primary histiocytosis X of the parieto-occipital lobe. Eriksen, B., Janinis, J., Variakojis, D., Winter, J., Russel, E., Marder, R., DalCanto, M.C. Hum. Pathol. (1988) [Pubmed]
  27. Eosinophilic pancreatitis and increased eosinophils in the pancreas. Abraham, S.C., Leach, S., Yeo, C.J., Cameron, J.L., Murakata, L.A., Boitnott, J.K., Albores-Saavedra, J., Hruban, R.H. Am. J. Surg. Pathol. (2003) [Pubmed]
  28. Hemophagocytic histiocytosis (HH) in renal transplant recipients under ciclosporin therapy: report of the first two cases. Calonge, V.M., Glotz, D., Bouscary, D., Duboust, A., Bruneval, P., Druet, P., Diebold, J., Nochy, D. Clinical transplantation. (1995) [Pubmed]
  29. Unusual clinical manifestation of virus-associated hemophagocytic syndrome. Buza, N., Bálint, I., Schneider, T., Koltai, L., Orosz, Z. Pathol. Res. Pract. (2003) [Pubmed]
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