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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Vesicle targeting: timed release and specificity for leukocytes in mice by subcutaneous injection.

When unilamellar vesicles were administered subcutaneously in mice, the half-time for the destruction of the vesicles varied from 12 to 600 hours, depending on their composition. The vesicles tested consisted of distearoyl phosphatidylcholine, cholesterol, and certain sugar and amino-sugar derivatives of cholesterol. Vesicle with amino-sugar derivatives showed the greatest longevity and became localized with high specificity in aggregates of polymorphonuclear leukocytes. A substantial delay between the time that the vesicles broke open and the time that labels contained in the vesicles were excreted suggests that the vesicles undergo endocytosis before destruction.[1]

References

  1. Vesicle targeting: timed release and specificity for leukocytes in mice by subcutaneous injection. Mauk, M.R., Gamble, R.C., Baldeschwieler, J.D. Science (1980) [Pubmed]
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