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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Sleep-promoting material from human urine and its relation to factor S from brain.

A sleep-promoting factor was extracted from human urine. Intraventricular infusion of the purified material induced excess slow-wave sleep in rats and rabbits for 5--10 h after the infusion. Chemical properties of the urinary factor were similar to those of factor S derived from whole brains of sleep-deprived goats, sheep, and rabbits. The behavior of the urinary factor in two ion exchange chromatographic steps, high voltage electrophoresis, gel-filtration, and ultrafiltration was similar to that of factor S. Effects of the purified urinary factor on slow-wave sleep of rats and rabbits were similar in time-course and duration to those of factor S from brain. However, the factor obtained from human urine did not increase the amplitude of cortical slow waves to the same extent as did factor S from brains of sleep-deprived animals.[1]


  1. Sleep-promoting material from human urine and its relation to factor S from brain. Krueger, J.M., Bacsik, J., García-Arrarás, J. Am. J. Physiol. (1980) [Pubmed]
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