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Disease relevance of Ultrafiltration


Psychiatry related information on Ultrafiltration


High impact information on Ultrafiltration

  • A trend toward restricted transglomerular transport of neutral dextrans (radii, 2.4 to 5.8 nm) in cyclosporine-treated recipients suggested an intrinsic loss of ultrafiltration capacity by glomerular capillaries rather than a hemodynamic basis for the reduced glomerular filtration rate [7].
  • In the oligotrophic North Atlantic and North Pacific, ultrafiltration studies show that concentrations of soluble iron and soluble iron-binding organic ligands are much lower than previously presumed "dissolved" concentrations, which were operationally defined as that passing through a 0.4-micrometer pore filter [8].
  • DESIGN: In vitro studies comparing measurements of total and free T4 and T3 by ultrafiltration assay (undiluted serum) and a commercial free T4 estimate kit in control serum samples or serum samples containing added therapeutic levels of phenytoin or carbamazepine [9].
  • We treated eight severely hypertensive, long-term hemodialysis patients who failed to respond to ultrafiltration or conventional medication with minoxidil rather than with bilateral nephrectomy [10].
  • Micropuncture studies demonstrated reduced single nephron plasma flow and glomerular filtration rates, increased transcapillary hydraulic pressure difference, pre- and postglomerular resistances, and decreased ultrafiltration coefficient in PHN rats [11].

Chemical compound and disease context of Ultrafiltration


Biological context of Ultrafiltration


Anatomical context of Ultrafiltration


Associations of Ultrafiltration with chemical compounds

  • In group 2 diabetic rats infusion of insulin to achieve acute blood glucose control normalized the glomerular transcapillary pressure gradient while increasing the glomerular ultrafiltration coefficient, so that SNGFR remained elevated [26].
  • Extrapolated to 4 X 2 liters, 2.5% dextrose, 6-h exchanges per d, lymphatic drainage reduced potential daily net ultrafiltration by 83.2 +/- 10.2%, daily urea clearance by 16.9 +/- 1.9%, and daily creatinine clearance by 16.5 +/- 1.9% [27].
  • In similarly prepared rats, dietary protein restriction (6% vs. 20%) led to a lower glomerular capillary hydraulic pressure, a higher ultrafiltration coefficient, and similar single nephron filtration rates [28].
  • The ER4 antibody-induced fall in GFR was mainly caused by a marked decrement in the ultrafiltration coefficient, Kf, which was dependent on TxA2 and 5-lipoxygenase products, since pretreatment of animals with a thromboxane receptor antagonist or with a 5-lipoxygenase inhibitor partially ameliorated this decrement [29].
  • Infusion of saralasin to these water-deprived rats resulted in significant increases in plasma flow rate and ultrafiltration coefficient, and decline in arteriolar resistances [30].

Gene context of Ultrafiltration


Analytical, diagnostic and therapeutic context of Ultrafiltration


  1. Preservation of the glomerular capillary ultrafiltration coefficient during rat nephrotoxic serum nephritis by a specific leukotriene D4 receptor antagonist. Badr, K.F., Schreiner, G.F., Wasserman, M., Ichikawa, I. J. Clin. Invest. (1988) [Pubmed]
  2. Moderate hypothermia for uncontrolled intracranial hypertension in acute liver failure. Jalan, R., Damink, S.W., Deutz, N.E., Lee, A., Hayes, P.C. Lancet (1999) [Pubmed]
  3. Thiopental infusion in the treatment of intracranial hypertension complicating fulminant hepatic failure. Forbes, A., Alexander, G.J., O'Grady, J.G., Keays, R., Gullan, R., Dawling, S., Williams, R. Hepatology (1989) [Pubmed]
  4. Stimulation of rat peritoneal mast cell migration by tumor-derived peptides. Poole, T.J., Zetter, B.R. Cancer Res. (1983) [Pubmed]
  5. Glomerular proteoglycans in diabetes. Partial structural characterization and metabolism of de novo synthesized heparan-35SO4 and dermatan-35SO4 proteoglycans in streptozocin-induced diabetic rats. Klein, D.J., Brown, D.M., Oegema, T.R. Diabetes (1986) [Pubmed]
  6. Sleep-promoting material from human urine and its relation to factor S from brain. Krueger, J.M., Bacsik, J., García-Arrarás, J. Am. J. Physiol. (1980) [Pubmed]
  7. Cyclosporine-associated chronic nephropathy. Myers, B.D., Ross, J., Newton, L., Luetscher, J., Perlroth, M. N. Engl. J. Med. (1984) [Pubmed]
  8. Soluble and colloidal iron in the oligotrophic North Atlantic and North Pacific. Wu, J., Boyle, E., Sunda, W., Wen, L.S. Science (2001) [Pubmed]
  9. Normal serum free thyroid hormone concentrations in patients treated with phenytoin or carbamazepine. A paradox resolved. Surks, M.I., DeFesi, C.R. JAMA (1996) [Pubmed]
  10. Minoxidil treatment of malignant hypertension. Recovery of renal function. Luft, F.C., Bloch, R., Szwed, J.J., Grim, C.M., Grim, C.E. JAMA (1978) [Pubmed]
  11. Leukotriene D4 is a mediator of proteinuria and glomerular hemodynamic abnormalities in passive Heymann nephritis. Katoh, T., Lianos, E.A., Fukunaga, M., Takahashi, K., Badr, K.F. J. Clin. Invest. (1993) [Pubmed]
  12. Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats. Körner, A., Celsi, G., Eklöf, A.C., Linné, T., Persson, B., Aperia, A. Diabetologia (1992) [Pubmed]
  13. High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells. Ha, H., Yu, M.R., Lee, H.B. Kidney Int. (2001) [Pubmed]
  14. Mechanism of action of Yersinia enterocolitica enterotoxin. Robins-Browne, R.M., Still, C.S., Miliotis, M.D., Koornhof, H.J. Infect. Immun. (1979) [Pubmed]
  15. Clinical utility of measuring free thyroxin and free triiodothyronine in serum of critically ill patients by ultrafiltration. Lee, L.A., Mooney, R.A., Woolf, P.D. Clin. Chem. (1986) [Pubmed]
  16. Modulation of glomerular hypertension defines susceptibility to progressive glomerular injury. Simons, J.L., Provoost, A.P., Anderson, S., Rennke, H.G., Troy, J.L., Brenner, B.M. Kidney Int. (1994) [Pubmed]
  17. Atrial natriuretic factor and liver disease. Warner, L., Skorecki, K., Blendis, L.M., Epstein, M. Hepatology (1993) [Pubmed]
  18. Mechanisms of glomerular immune injury: effects of antioxidant treatment. Narsipur, S.S., Peterson, O.W., Smith, R., Bigby, T.D., Parthasarathy, S., Gabbai, F.B., Wilson, C.B., Blantz, R.C. J. Am. Soc. Nephrol. (2003) [Pubmed]
  19. Disposition of drugs in cystic fibrosis. VI. In vivo activity of cytochrome P450 isoforms involved in the metabolism of (R)-warfarin (including P450 3A4) is not enhanced in cystic fibrosis. Wang, J.P., Unadkat, J.D., McNamara, S., O'Sullivan, T.A., Smith, A.L., Trager, W.F., Ramsey, B. Clin. Pharmacol. Ther. (1994) [Pubmed]
  20. Transport of equine estrogens: binding of conjugated and unconjugated equine estrogens with human serum proteins. Pan, C.C., Woolever, C.A., Bhavnani, B.R. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  21. Kinetics of binding of [3H]acetylcholine to Torpedo postsynaptic membranes: association and dissociation rate constants by rapid mixing and ultrafiltration. Boyd, N.D., Cohen, J.B. Biochemistry (1980) [Pubmed]
  22. Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat. Blantz, R.C., Konnen, K.S., Tucker, B.J. J. Clin. Invest. (1976) [Pubmed]
  23. Regulation of glucose-6-phosphate dehydrogenase in human erythrocytes. Kirkman, H.N., Gaetani, G.F. J. Biol. Chem. (1986) [Pubmed]
  24. Synergistic regulation of pulmonary beta-adrenergic receptors by glucocorticoids and interleukin-1. Stern, L., Kunos, G. J. Biol. Chem. (1988) [Pubmed]
  25. Purification and biologic properties of fibroblast somatomedin. Clemmons, D.R., Shaw, D.S. J. Biol. Chem. (1986) [Pubmed]
  26. Control of glomerular hypertension by insulin administration in diabetic rats. Scholey, J.W., Meyer, T.W. J. Clin. Invest. (1989) [Pubmed]
  27. Contribution of lymphatic absorption to loss of ultrafiltration and solute clearances in continuous ambulatory peritoneal dialysis. Mactier, R.A., Khanna, R., Twardowski, Z., Moore, H., Nolph, K.D. J. Clin. Invest. (1987) [Pubmed]
  28. Dietary protein restriction in established renal injury in the rat. Selective role of glomerular capillary pressure in progressive glomerular dysfunction. Nath, K.A., Kren, S.M., Hostetter, T.H. J. Clin. Invest. (1986) [Pubmed]
  29. Mesangial cell immune injury. Hemodynamic role of leukocyte- and platelet-derived eicosanoids. Bresnahan, B.A., Wu, S., Fenoy, F.J., Roman, R.J., Lianos, E.A. J. Clin. Invest. (1992) [Pubmed]
  30. Mechanism of preservation of glomerular perfusion and filtration during acute extracellular fluid volume depletion. Importance of intrarenal vasopressin-prostaglandin interaction for protecting kidneys from constrictor action of vasopressin. Yared, A., Kon, V., Ichikawa, I. J. Clin. Invest. (1985) [Pubmed]
  31. Measurement of intact insulin-like growth factor-binding protein-3 in human plasma using a ligand immunofunctional assay. Lassarre, C., Binoux, M. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  32. Measurement of eotaxin (CCL11) in induced sputum supernatants: validation and detection in asthma. Hadjicharalambous, C., Dent, G., May, R.D., Handy, R.L., Anderson, I.K., Davies, D.E., Djukanovic, R. J. Allergy Clin. Immunol. (2004) [Pubmed]
  33. Expression of aquaporin-3 in human peritoneal mesothelial cells and its up-regulation by glucose in vitro. Lai, K.N., Leung, J.C., Chan, L.Y., Tang, S., Li, F.K., Lui, S.L., Chan, T.M. Kidney Int. (2002) [Pubmed]
  34. Endothelin-1 inhibits cytokine-stimulated transcription of inducible nitric oxide synthase in glomerular mesangial cells. Beck, K.F., Mohaupt, M.G., Sterzel, R.B. Kidney Int. (1995) [Pubmed]
  35. Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry. Nikolic, D., Habibi-Goudarzi, S., Corley, D.G., Gafner, S., Pezzuto, J.M., van Breemen, R.B. Anal. Chem. (2000) [Pubmed]
  36. A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat. Kon, V., Harris, R.C., Ichikawa, I. J. Clin. Invest. (1990) [Pubmed]
  37. Effect of mucous glycoprotein on nucleation time of human bile. Gallinger, S., Taylor, R.D., Harvey, P.R., Petrunka, C.N., Strasberg, S.M. Gastroenterology (1985) [Pubmed]
  38. Dynamic properties of isolated acetylcholine receptor proteins: release of calcium ions caused by acetylcholine binding. Chang, H.W., Neumann, E. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  39. Effects of norepinephrine and angiotensin II on the determinants of glomerular ultrafiltration and proximal tubule fluid reabsorption in the rat. Myers, B.D., Deen, W.M., Brenner, B.M. Circ. Res. (1975) [Pubmed]
  40. Isolation and partial characterization of a 67Ga-binding glycoprotein from Morris 5123C rat hepatoma. Lawless, D., Brown, D.H., Hübner, K.F., Colyer, S.P., Carlton, J.E., Hayes, R.L. Cancer Res. (1978) [Pubmed]
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