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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Therapeutic effects of ML-236B in primary hypercholesterolemia.

ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase, was administered to 11 patients with primary hypercholesterolemia. After 4--8 weeks of drug treatment at doses of 50--150 mg/day, serum cholesterol levels were reduced by 11--37% (27% on average) in cases of heterozygous familial hypercholesterolemia and combined hyperlipidemia. A marked reduction in tuberous xanthomas was noticed in a homozygous case of familial hypercholesterolemia, but here the drug was less effective in reducing the serum cholesterol level and a higher dose was required for treatment. Softening of Achilles tendon xantomas was observed in a case of combined hyperlipidemia.[1]


  1. Therapeutic effects of ML-236B in primary hypercholesterolemia. Yamamoto, A., Sudo, H., Endo, A. Atherosclerosis (1980) [Pubmed]
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