The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

compactin     [(1S,7R,8S,8aS)-8-[2- [(2R,4R)-4-hydroxy-6...

Synonyms: Mevastatin, Mevastatina, Mevastatine, Mevastatinum, SureCN1116, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mevastatin


High impact information on Mevastatin


Chemical compound and disease context of Mevastatin


Biological context of Mevastatin


Anatomical context of Mevastatin

  • In contrast, blockade of p21ras isoprenylation and membrane association by compactin treatment did not significantly reduce PC12 cell responses to NGF [9].
  • The crystalloid endoplasmic reticulum (ER), a specialized smooth ER of the compactin-resistant UT-1 cell, is composed of multiple membrane tubules packed together in a hexagonal pattern [14].
  • With longer times of incubation in the presence of compactin, these cells had lamellar stacks of smooth ER next to the nuclear envelope that contained HMG CoA reductase [14].
  • We used two model systems to investigate the effect of compactin, a competitive inhibitor of beta-hydroxy beta-methylglutarylcoenzyme A reductase, on the shape of Swiss 3T3 cells [18].
  • After 15 h of incubation in the presence of compactin, many cells had profiles of ER cisternae that were juxtaposed to the nuclear envelope and studded with ribosomes on their outer membrane [14].

Associations of Mevastatin with other chemical compounds


Gene context of Mevastatin


Analytical, diagnostic and therapeutic context of Mevastatin


  1. p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases. Ukomadu, C., Dutta, A. J. Biol. Chem. (2003) [Pubmed]
  2. The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates. van beek, E., Löwik, C., van der Pluijm, G., Papapoulos, S. J. Bone Miner. Res. (1999) [Pubmed]
  3. Compactin (ML-236B) reduces the content of filipin-cholesterol complexes in the plasma membrane of chronic lymphocytic leukemia cells. Madden, E.A., Melnykovych, G., Fiskin, A.M. Exp. Cell Res. (1984) [Pubmed]
  4. The effect of mevalonic acid deprivation on enzymes of DNA replication in cells emerging from quiescence. Silber, J.R., Galick, H., Wu, J.M., Siperstein, M.D. Biochem. J. (1992) [Pubmed]
  5. HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Wächtershäuser, A., Akoglu, B., Stein, J. Carcinogenesis (2001) [Pubmed]
  6. Reduction of serum cholesterol in heterozygous patients with familial hypercholesterolemia. Additive effects of compactin and cholestyramine. Mabuchi, H., Sakai, T., Sakai, Y., Yoshimura, A., Watanabe, A., Wakasugi, T., Koizumi, J., Takeda, R. N. Engl. J. Med. (1983) [Pubmed]
  7. Effect of an inhibitor of 3-hydroxy-3-methyglutaryl coenzyme A reductase on serum lipoproteins and ubiquinone-10-levels in patients with familial hypercholesterolemia. Mabuchi, H., Haba, T., Tatami, R., Miyamoto, S., Sakai, Y., Wakasugi, T., Watanabe, A., Koizumi, J., Takeda, R. N. Engl. J. Med. (1981) [Pubmed]
  8. Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells. Bokoch, G.M., Prossnitz, V. J. Clin. Invest. (1992) [Pubmed]
  9. ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells. Qiu, M.S., Pitts, A.F., Winters, T.R., Green, S.H. J. Cell Biol. (1991) [Pubmed]
  10. Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. Woo, J.T., Kasai, S., Stern, P.H., Nagai, K. J. Bone Miner. Res. (2000) [Pubmed]
  11. Screening of compactin-resistant microorganisms capable of converting compactin to pravastatin. Chen, C.H., Hu, H.Y., Cho, Y.C., Hsu, W.H. Curr. Microbiol. (2006) [Pubmed]
  12. Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance. Hirata, D., Yano, K., Miyahara, K., Miyakawa, T. Curr. Genet. (1994) [Pubmed]
  13. Cloning and sequencing of the 3-phosphoglycerate kinase (PGK) gene from Penicillium citrinum and its application to heterologous gene expression. Nara, F., Watanabe, I., Serizawa, N. Curr. Genet. (1993) [Pubmed]
  14. Biogenesis of the crystalloid endoplasmic reticulum in UT-1 cells: evidence that newly formed endoplasmic reticulum emerges from the nuclear envelope. Pathak, R.K., Luskey, K.L., Anderson, R.G. J. Cell Biol. (1986) [Pubmed]
  15. Isopentenyladenine as a mediator of mevalonate-regulated DNA replication. Huneeus, V.Q., Wiley, M.H., Siperstein, M.D. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  16. Inhibition of polyisoprenoid and glycoprotein biosynthesis causes abnormal embryonic development. Carson, D.D., Lennarz, W.J. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  17. Cell cycle regulation of metallothionein in human colonic cancer cells. Nagel, W.W., Vallee, B.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  18. A study of the Influence of mevalonic acid and its metabolites on the morphology of swiss 3T3 cells. Schmidt, R.A., Glomset, J.A., Wight, T.N., Habenicht, A.J., Ross, R. J. Cell Biol. (1982) [Pubmed]
  19. The effect of CS-514 on serum lipids and apolipoproteins in hypercholesterolemic subjects. Nakaya, N., Homma, Y., Tamachi, H., Shigematsu, H., Hata, Y., Goto, Y. JAMA (1987) [Pubmed]
  20. Regulation of low-density lipoprotein receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis. Goldstein, J.L., Brown, M.S. Circulation (1987) [Pubmed]
  21. Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Chin, D.J., Luskey, K.L., Anderson, R.G., Faust, J.R., Goldstein, J.L., Brown, M.S. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  22. Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells. Faust, J.R., Luskey, K.L., Chin, D.J., Goldstein, J.L., Brown, M.S. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  23. Inhibition of hydroxymethylglutaryl coenzyme A reductase activity induces a paradoxical increase in DNA synthesis in myeloid leukemia cells. Hohl, R.J., Larson, R.A., Mannickarottu, V., Yachnin, S. Blood (1991) [Pubmed]
  24. Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Basson, M.E., Thorsness, M., Rine, J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  25. Inhibition of cdk2 activating phosphorylation by mevastatin. Ukomadu, C., Dutta, A. J. Biol. Chem. (2003) [Pubmed]
  26. Determination of mRNA levels of cholesterol biosynthesis enzymes and LDL receptor using ribonuclease protection assay. Shimokawa, T., Kawabe, Y., Honda, M., Yazaki, Y., Matsumoto, A., Itakura, H., Kodama, T. J. Lipid Res. (1995) [Pubmed]
  27. Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Sugiyama, M., Kodama, T., Konishi, K., Abe, K., Asami, S., Oikawa, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  28. GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells. Miquel, K., Pradines, A., Sun, J., Qian, Y., Hamilton, A.D., Sebti, S.M., Favre, G. Cancer Res. (1997) [Pubmed]
  29. Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr). Yan, D., Swain, P.K., Breuer, D., Tucker, R.M., Wu, W., Fujita, R., Rehemtulla, A., Burke, D., Swaroop, A. J. Biol. Chem. (1998) [Pubmed]
  30. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted [1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives. Stokker, G.E., Alberts, A.W., Anderson, P.S., Cragoe, E.J., Deana, A.A., Gilfillan, J.L., Hirshfield, J., Holtz, W.J., Hoffman, W.F., Huff, J.W. J. Med. Chem. (1986) [Pubmed]
  31. Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). Woo, J.T., Nakagawa, H., Krecic, A.M., Nagai, K., Hamilton, A.D., Sebti, S.M., Stern, P.H. Biochem. Pharmacol. (2005) [Pubmed]
  32. Hypolipidemic effects of CS-500 (ML-236B) in WHHL-rabbit, a heritable animal model for hyperlipidemia. Watanabe, Y., Ito, T., Saeki, M., Kuroda, M., Tanzawa, K., Mochizuki, M., Tsujita, Y., Arai, M. Atherosclerosis (1981) [Pubmed]
WikiGenes - Universities