The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Nonanoic acid irritation - a positive control at routine patch testing?

A false negative patch test can be related to errors in the testing procedure, or to a defect in the eliciting (efferent) phase of the immune response. To define this phase the application of a topical irritant (a "positive control") is suggested. Various concentrations of nonanoic acid in 1-propanol were applied to 116 healthy volunteers and to 75 dermatitis patients. Dose-response curves were obtained (concentrations 5, 10, 20 and 39.9%). Twenty percent nonanoic acid produced skin reactions in 90.1--93.9% of the subjects. The lesions consisted mainly of erythema at 48 h and pigmentation at 96 h. We suggested that the most interesting patients are those negative to this primary irritant and thay they should be further evaluated.[1]


  1. Nonanoic acid irritation - a positive control at routine patch testing? Wahlberg, J.E., Maibach, H.I. Contact Derm. (1980) [Pubmed]
WikiGenes - Universities