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Chemical Compound Review

propanol     propan-1-ol

Synonyms: Propylol, Albacol, Propanole, Propanoli, n-propanol, ...
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Disease relevance of propanol


Psychiatry related information on propanol


High impact information on propanol

  • Plasmids can be dissected in propanol by increasing the force applied by the AFM tip at selected locations [8].
  • They are inactivated upon treatment with propanol, heat, and acid; the covalent and equimolar complexes formed between these PAIs and 125I-uPA are dissociated by ammonium hydroxide, suggesting that the PAIs are linked to uPA via an ester bond [9].
  • For alcohols with a molecular volume of < or = 42.2 ml/mol, potency for inhibiting ATP-activated current was correlated with lipid solubility (order of potency: 1-propanol = trifluoroethanol > monochloroethanol > ethanol > methanol) [10].
  • 1-Propanol induces the alpha-helical conformation into RNase S peptide also [1].
  • On HPLC, the putative proenkephalin was eluted at a much higher propanol concentration than the 18.2-kDa enkephalin-containing peptide isolated previously [11].

Chemical compound and disease context of propanol


Biological context of propanol

  • Reduction and alkylation of bovine insulin (pH 8.3, aq. 50% propanol) gives fully S-substituted derivatives in excellent yields [17].
  • Experiments with a structure inducer, 15% 1-propanol in buffer, reveal that the refolding pattern of MBP in reverse micelles is specific to the membrane biomimetic system and is not produced by organic solvent per se [18].
  • 2.5% propanol-1 for 15 min induces a slight reduction of cell growth but a clear-cut overexpression of stress proteins [19].
  • The phenomenon, first observed for n-propanol (Goresky et al., Am. J Physiol. 244: G215-G244, 1983a), is explained by a nonsaturable (partition coefficient, 3.8-5) and a saturable binding (binding site concentration, 352-98 microM) component in the tissue [20].
  • Sol-gel hydrolysis reactions in propanol of two or more metal acetates or alkoxides in n-alkylamines have been found to yield porous mixed oxides with the presence of pores largely in the 10-20 [Angstrom] region [21].

Anatomical context of propanol

  • PMA similarly stimulated [14C]phosphatidylpropanol formation from propanol using membranes from [14C]myristic acid-prelabeled cells, confirming the activation of PLD [22].
  • Based on the respiratory control index, the order of potency for impairment of mitochondria was PG > PG-dimer > gallic acid = 4-O-methyl-gallic acid = ellagic acid - propyl alcohol [23].
  • Capillary multipurpose columns were prepared in silanized fused-silica capillaries of 50, 75, and 100 microm inner diameters by thermally induced in situ copolymerization of methacrylic monomers in the presence of n-propanol and formamide as porogens and azobisisobutyronitrile as initiator [24].
  • Incubation of rat liver microsomes with 1-propanol and 1-butanol in the presence of NADPH and of the spin trapping agent 4-pyridyl-1-oxide-t-butyl nitrone (4-POBN) allowed the detection of free radical intermediates tentatively identified as 1-hydroxypropyl and 1-hydroxybutyl radical, respectively [25].
  • In addition, PDGF-BB stimulated the accumulation of phosphatidylpropanol, produced by phospholipase D phosphatidyl transferase activity, when 1-propanol was added to mesangial cells [26].

Associations of propanol with other chemical compounds


Gene context of propanol

  • In the present study, we investigated the effect of the NR2B-selective NMDA receptor antagonist Ro 25-6981 [(+/-)-(R*,S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propanol] on nicotine-stimulated LMA and nicotine-induced DA release in the nucleus accumbens (NAcc) in rats [32].
  • First of all, as propanol is synthesised from alpha-ketobutyrate, the first metabolic intermediate in the anabolic pathway of isoleucine, neither the eca39 nor eca40 mutations have any effect on the production of this higher alcohol [33].
  • In contrast to WI38, both cSrc and MAPK in VA13 were strongly activated regardless of FGF stimulation or GM3 depletion by P4 [34].
  • R-(R*,S*)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenyl-methyl)-1-piperidine propanol (RO 25-6981), is a high-affinity and selective blocker of NMDA receptors containing the NR2B subunit [35].
  • Butanol produced a maximal 37-42% increase in prolactin binding at a concentration of 1.0%, propanol produced a maximal 40-56% increase in prolactin binding at a concentration of 3.8%, and ethanol produced a maximal 54-77% increase in prolactin binding at concentration of 4.8% [36].

Analytical, diagnostic and therapeutic context of propanol

  • To determine whether the changes in glycolipid content were functionally significant, diabetic and control groups were treated with the GlcCer synthase inhibitor, D-threo-1-phenyl-2-decanoyl-amino-3-morpholino-1- propanol, 2 wk after the induction of diabetes [37].
  • To test the hypothesis that conformational alterations might be involved in the elution of proteins from reversed-phase HPLC columns, the conformations of proteins bound onto a C-8 alkyl-bonded silica surface have been examined in the presence of increasing concentrations of the commonly employed eluent, 1-propanol [38].
  • Reproducible images of pBR322 plasmid molecules have been recorded by scanning force microscopy under 1-propanol [39].
  • Reverse phase high performance liquid chromatography (HPLC) (C3) revealed one major CN-Br 32P-peptide (CB1) that eluted at about 6% propanol [40].
  • SIRS-beta elutes in 30% propanol, and on isoelectric focusing the biologic activity is found only at approximately pH7 (SIRS-beta 7) [41].


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  2. Atomic force microscopy of DNA in aqueous solutions. Hansma, H.G., Bezanilla, M., Zenhausern, F., Adrian, M., Sinsheimer, R.L. Nucleic Acids Res. (1993) [Pubmed]
  3. Atomic force microscopy of DNA and bacteriophage in air, water and propanol: the role of adhesion forces. Lyubchenko, Y.L., Oden, P.I., Lampner, D., Lindsay, S.M., Dunker, K.A. Nucleic Acids Res. (1993) [Pubmed]
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  7. Ethanol production by Candida albicans in postmortem human blood samples: Effects of blood glucose level and dilution. Yajima, D., Motani, H., Kamei, K., Sato, Y., Hayakawa, M., Iwase, H. Forensic Sci. Int. (2006) [Pubmed]
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  11. Intact proenkephalin is the major enkephalin-containing peptide produced in rat adrenal glands after denervation. Fleminger, G., Howells, R.D., Kilpatrick, D.L., Udenfriend, S. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  12. Secretion of proteins by Bacillus subtilis 168 grown in the presence of membrane active agents (alcohols). Baykousheva, S. J. Chromatogr. (1988) [Pubmed]
  13. Cutaneous reactions to lower aliphatic alcohols before and during disulfiram therapy. Haddock, N.F., Wilkin, J.K. Archives of dermatology. (1982) [Pubmed]
  14. Novel efficient mesoporous solid acid catalyst UDCaT-4: dehydration of 2-propanol and alkylation of mesitylene. Yadav, G.D., Murkute, A.D. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
  15. Lession on the hypothalamic arcuate nucleus by estradiol valerate results in a blockade of ethanol-induced locomotion. Sanchis-Segura, C., Correa, M., Aragon, C.M. Behav. Brain Res. (2000) [Pubmed]
  16. A comparison of the effects of cationic, anionic, and neutral amphipathic agents on the contractile behaviour of frog skeletal muscle. II. Amplitude of depolarization and repolarization-induced contractures. Foulks, J.G., Morishita, L. Can. J. Physiol. Pharmacol. (1984) [Pubmed]
  17. 4-pyridylmethyl, a thiol-protecting group suitable for the partial synthesis of proteins. Rüegg, U.T., Jarvis, D., Rudinger, J. Biochem. J. (1979) [Pubmed]
  18. Limited proteolysis of myelin basic protein in a system mimetic of the myelin interlamellar aqueous space. Nicot, C., Vacher, M., Denoroy, L., Kahn, P.C., Waks, M. J. Neurochem. (1993) [Pubmed]
  19. Expression of stress proteins in cultured HT29 human cell-line; a model for studying environmental aggression. Delmas, F., Trocheris, V., Murat, J.C. Int. J. Biochem. Cell Biol. (1995) [Pubmed]
  20. Demonstration of rapid entry and a cellular binding space for salicylamide in perfused rat liver: a multiple indicator dilution study. Pang, K.S., Barker, F., Schwab, A.J., Goresky, C.A. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  21. New families of supermicroporous metal oxides: the link between zeolites and mesoporous materials. Shpeizer, B.G., Clearfield, A., Heising, J.M. Chem. Commun. (Camb.) (2005) [Pubmed]
  22. Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism. Conricode, K.M., Brewer, K.A., Exton, J.H. J. Biol. Chem. (1992) [Pubmed]
  23. Metabolism and cytotoxicity of propyl gallate in isolated rat hepatocytes: effects of a thiol reductant and an esterase inhibitor. Nakagawa, Y., Nakajima, K., Tayama, S., Moldéus, P. Mol. Pharmacol. (1995) [Pubmed]
  24. High-efficiency peptide analysis on monolithic multimode capillary columns: Pressure-assisted capillary electrochromatography/capillary electrophoresis coupled to UV and electrospray ionization-mass spectrometry. Ivanov, A.R., Horváth, C., Karger, B.L. Electrophoresis (2003) [Pubmed]
  25. Role of ethanol-inducible cytochrome P450 (P450IIE1) in catalysing the free radical activation of aliphatic alcohols. Albano, E., Tomasi, A., Persson, J.O., Terelius, Y., Goria-Gatti, L., Ingelman-Sundberg, M., Dianzani, M.U. Biochem. Pharmacol. (1991) [Pubmed]
  26. Effects of homo- and heterodimeric isoforms of PDGF on signalling events in rat renal mesangial cells. Pfeilschifter, J., Hosang, M. Cell. Signal. (1991) [Pubmed]
  27. Epidermal growth factor-like transforming growth factor. I. Isolation, chemical characterization, and potentiation by other transforming factors from feline sarcoma virus-transformed rat cells. Massagué, J. J. Biol. Chem. (1983) [Pubmed]
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  29. Crystallization and preliminary X-ray diffraction studies of a peroxidase from barley grain. Henriksen, A., Petersen, J.F., Svensson, A., Hejgaard, J., Welinder, K.G., Gajhede, M. J. Mol. Biol. (1992) [Pubmed]
  30. Innocent and less-innocent solvent ligands: a systematic investigation of cationic iron chloride/alcohol complexes by electrospray ionization mass spectrometry complemented by DFT calculations. Trage, C., Diefenbach, M., Schröder, D., Schwarz, H. Chemistry (Weinheim an der Bergstrasse, Germany) (2006) [Pubmed]
  31. Proteome analysis of Sulfolobus solfataricus P2 propanol metabolism. Chong, P.K., Burja, A.M., Radianingtyas, H., Fazeli, A., Wright, P.C. J. Proteome Res. (2007) [Pubmed]
  32. The NR2B-selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(+/-)-(R*,S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamine release in the nucleus accumbens. Kosowski, A.R., Liljequist, S. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  33. Involvement of branched-chain amino acid aminotransferases in the production of fusel alcohols during fermentation in yeast. Eden, A., Van Nedervelde, L., Drukker, M., Benvenisty, N., Debourg, A. Appl. Microbiol. Biotechnol. (2001) [Pubmed]
  34. Cell growth regulation through GM3-enriched microdomain (glycosynapse) in human lung embryonal fibroblast WI38 and its oncogenic transformant VA13. Toledo, M.S., Suzuki, E., Handa, K., Hakomori, S. J. Biol. Chem. (2004) [Pubmed]
  35. Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket. Malherbe, P., Mutel, V., Broger, C., Perin-Dureau, F., Kemp, J.A., Neyton, J., Paoletti, P., Kew, J.N. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  36. Modulation of prolactin binding sites in vitro by membrane fluidizers. I. Effects on adult rat ventral prostatic membranes. Dave, J.R., Witorsch, R.J. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  37. A role for glycosphingolipid accumulation in the renal hypertrophy of streptozotocin-induced diabetes mellitus. Zador, I.Z., Deshmukh, G.D., Kunkel, R., Johnson, K., Radin, N.S., Shayman, J.A. J. Clin. Invest. (1993) [Pubmed]
  38. Role of conformational changes in the elution of proteins from reversed-phase HPLC columns. Katzenstein, G.E., Vrona, S.A., Wechsler, R.J., Steadman, B.L., Lewis, R.V., Middaugh, C.R. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  39. Chirality of DNA supercoiling assigned by scanning force microscopy. Samorí, B., Siligardi, G., Quagliariello, C., Weisenhorn, A.L., Vesenka, J., Bustamante, C.J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  40. Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains. Schworer, C.M., Colbran, R.J., Keefer, J.R., Soderling, T.R. J. Biol. Chem. (1988) [Pubmed]
  41. Purification and analysis of isoforms of soluble immune response suppressor (SIRS). Webb, D.R., Mason, K., Semenuk, G., Aune, T.M., Pierce, C.W. J. Immunol. (1985) [Pubmed]
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