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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Dermatitis


Psychiatry related information on Dermatitis


High impact information on Dermatitis


Chemical compound and disease context of Dermatitis


Biological context of Dermatitis

  • These findings suggest that in situ activation of LCs by CD40L in the skin not only leads to chronic inflammatory dermatitis but also to systemic mixed-connective-tissue-like autoimmune disorders, possibly by breaking immune tolerance against the skin [20].
  • Severe ulcerative dermatitis occurred in 56% of Sl/Sld mice at an average age o4f 441 +/- 21 days and in 20% of heterozygotes and homozygous normal controls at 722 +/- 50 days [21].
  • Collectively, these results suggest a complex inheritance pattern of psoriasiform dermatitis in this model that involves lowered, but not absent, CD18 expression and at least two additional PL/J loci for the development of severe disease [22].
  • Up-regulation of VAP-1 in experimental dermatitis and arthritis could be visualized by specifically targeted immunoscintigraphy [23].
  • The effect of fat malabsorption on the absorption and renal excretion of dietary oxalate was studied in four patients with sprue and in two patients with dermatitis herpetiformis and sprue-like jejunal histology [24].

Anatomical context of Dermatitis


Gene context of Dermatitis


Analytical, diagnostic and therapeutic context of Dermatitis


  1. Absence of toxicity of avenin in patients with dermatitis herpetiformis. Hardman, C., Fry, L., Tatham, A., Thomas, H.J. N. Engl. J. Med. (1999) [Pubmed]
  2. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. Moertel, C.G., Fleming, T.R., Macdonald, J.S., Haller, D.G., Laurie, J.A., Goodman, P.J., Ungerleider, J.S., Emerson, W.A., Tormey, D.C., Glick, J.H. N. Engl. J. Med. (1990) [Pubmed]
  3. HLA class II alpha chain gene polymorphisms in patients with insulin-dependent diabetes mellitus, dermatitis herpetiformis, and celiac disease. Hitman, G.A., Niven, M.J., Festenstein, H., Cassell, P.G., Awad, J., Walker-Smith, J., Leonard, J.N., Fry, L., Ciclitira, P., Kumar, P. J. Clin. Invest. (1987) [Pubmed]
  4. Induction of p53 expression in skin by radiotherapy and UV radiation: a randomized study. Ponten, F., Lindman, H., Bostrom, A., Berne, B., Bergh, J. J. Natl. Cancer Inst. (2001) [Pubmed]
  5. Small bowel malignant lymphoma complicating celiac sprue and the mesenteric lymph node cavitation syndrome. Freeman, H.J., Chiu, B.K. Gastroenterology (1986) [Pubmed]
  6. Stressful life events and skin diseases: disentangling evidence from myth. Picardi, A., Abeni, D. Psychotherapy and psychosomatics. (2001) [Pubmed]
  7. Niacin metabolite excretion in alcoholic pellagra and AIDS patients with and without diarrhea. Monteiro, J.P., da Cunha, D.F., Filho, D.C., Silva-Vergara, M.L., dos Santos, V.M., da Costa, J.C., Etchebehere, R.M., Gonçalves, J., de Carvalho da Cunha, S.F., Jordão, A.A., Chiarello, P.G., Vannucchi, H. Nutrition (Burbank, Los Angeles County, Calif.) (2004) [Pubmed]
  8. Nutritional disorders among workers in North China during national turmoil. Lee, B.Y., Thurmon, T.F. Ann. Nutr. Metab. (2001) [Pubmed]
  9. Clinical experience with leucovorin and 5-fluorouracil. Laufman, L.R., Brenckman, W.D., Stydnicki, K.A., Morgan, E.D., Collier, M., Knick, V.B., Duch, D.S., Mullin, R., Ferone, R. Cancer (1989) [Pubmed]
  10. Sleep deprivation-induced dermatitis: further support of nicotinic acid depletion in sleep deprivation. Reimund, E. Med. Hypotheses (1991) [Pubmed]
  11. Images in clinical medicine. Bacterial perianal dermatitis. Peltola, H. N. Engl. J. Med. (2000) [Pubmed]
  12. Topical tretinoin (retinoic acid) therapy for hyperpigmented lesions caused by inflammation of the skin in black patients. Bulengo-Ransby, S.M., Griffiths, C.E., Kimbrough-Green, C.K., Finkel, L.J., Hamilton, T.A., Ellis, C.N., Voorhees, J.J. N. Engl. J. Med. (1993) [Pubmed]
  13. Potent contact allergen in the rubber plant guayule (Parthenium argentatum). Rodriguez, E., Reynolds, G.W., Thompson, J.A. Science (1981) [Pubmed]
  14. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Dillon, S.R., Sprecher, C., Hammond, A., Bilsborough, J., Rosenfeld-Franklin, M., Presnell, S.R., Haugen, H.S., Maurer, M., Harder, B., Johnston, J., Bort, S., Mudri, S., Kuijper, J.L., Bukowski, T., Shea, P., Dong, D.L., Dasovich, M., Grant, F.J., Lockwood, L., Levin, S.D., LeCiel, C., Waggie, K., Day, H., Topouzis, S., Kramer, J., Kuestner, R., Chen, Z., Foster, D., Parrish-Novak, J., Gross, J.A. Nat. Immunol. (2004) [Pubmed]
  15. Fluorouracil-associated dermatitis of the hands and feet. Feldman, L.D., Ajani, J.A. JAMA (1985) [Pubmed]
  16. Contact dermatitis to neomycin sulfate. Leyden, J.J., Kligman, A.M. JAMA (1979) [Pubmed]
  17. Dermatitis induced by warfarin. Kwong, P., Roberts, P., Prescott, S.M., Tikoff, G. JAMA (1978) [Pubmed]
  18. Athletic shoe dermatitis. Contact allergy to ethyl butyl thiourea. Roberts, J.L., Hanifin, J.M. JAMA (1979) [Pubmed]
  19. Occupational dermatitis associated with straw itch mites (Pyemotes ventricosus). Betz, T.G., Davis, B.L., Fournier, P.V., Rawlings, J.A., Elliot, L.B., Baggett, D.A. JAMA (1982) [Pubmed]
  20. Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. Mehling, A., Loser, K., Varga, G., Metze, D., Luger, T.A., Schwarz, T., Grabbe, S., Beissert, S. J. Exp. Med. (2001) [Pubmed]
  21. Effects of mutant steel alleles on leukemogenesis and life-span in the mouse. Murphy, E.D. J. Natl. Cancer Inst. (1977) [Pubmed]
  22. Psoriasiform dermatitis susceptibility in Itgb2(tm1Bay) PL/J mice requires low-level CD18 expression and at least two additional loci for progression to severe disease. Barlow, S.C., Collins, R.G., Ball, N.J., Weaver, C.T., Schoeb, T.R., Bullard, D.C. Am. J. Pathol. (2003) [Pubmed]
  23. In vivo detection of vascular adhesion protein-1 in experimental inflammation. Jaakkola, K., Nikula, T., Holopainen, R., Vähäsilta, T., Matikainen, M.T., Laukkanen, M.L., Huupponen, R., Halkola, L., Nieminen, L., Hiltunen, J., Parviainen, S., Clark, M.R., Knuuti, J., Savunen, T., Kääpä, P., Voipio-Pulkki, L.M., Jalkanen, S. Am. J. Pathol. (2000) [Pubmed]
  24. Hyperoxaluria correlates with fat malabsorption in patients with sprue. McDonald, G.B., Earnest, D.L., Admirand, W.H. Gut (1977) [Pubmed]
  25. Identification of C3 beta chain as the human serum eosinophil cytotoxicity inhibitor. Minkoff, M.S., Wong, W.W., Silberstein, D.S. J. Exp. Med. (1991) [Pubmed]
  26. Serological markers and HLA genes among healthy first-degree relatives of patients with coeliac disease. Mäki, M., Holm, K., Lipsanen, V., Hällström, O., Viander, M., Collin, P., Savilahti, E., Koskimies, S. Lancet (1991) [Pubmed]
  27. Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Francis, S.A., Shen, X., Young, J.B., Kaul, P., Lerner, D.J. Blood (2006) [Pubmed]
  28. Keratinocyte intercellular adhesion molecule-1 (ICAM-1) expression precedes dermal T lymphocytic infiltration in allergic contact dermatitis (Rhus dermatitis). Griffiths, C.E., Nickoloff, B.J. Am. J. Pathol. (1989) [Pubmed]
  29. T cells of atopic asthmatics preferentially infiltrate into human bronchial xenografts in SCID mice. Tsumori, K., Kohrogi, H., Goto, E., Hirata, N., Hirosako, S., Fujii, K., Ando, M., Kawano, O., Mizuta, H. J. Immunol. (2003) [Pubmed]
  30. The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance. Schwartz, D.R., Homanics, G.E., Hoyt, D.G., Klein, E., Abernethy, J., Lazo, J.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  31. IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice. Klement, J.F., Rice, N.R., Car, B.D., Abbondanzo, S.J., Powers, G.D., Bhatt, P.H., Chen, C.H., Rosen, C.A., Stewart, C.L. Mol. Cell. Biol. (1996) [Pubmed]
  32. The IKK-2/Ikappa Balpha /NF-kappa B pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in Ikappa Balpha -deficient mice. Huber, M.A., Denk, A., Peter, R.U., Weber, L., Kraut, N., Wirth, T. J. Biol. Chem. (2002) [Pubmed]
  33. Demonstration of tissue 90 kD glycoprotein as antigen in circulating IgG immune complexes in dermatitis herpetiformis and coeliac disease. Maury, C.P., Teppo, A.M. Lancet (1984) [Pubmed]
  34. Side effects of chemotherapy. Case 1. Radiation recall dermatitis from gemcitabine. Burstein, H.J. J. Clin. Oncol. (2000) [Pubmed]
  35. Effects of dermatitis, stripping, and steroids on the morphology of corneocytes. A new bioassay. Hölzle, E., Plewig, G. J. Invest. Dermatol. (1977) [Pubmed]
  36. Prophylaxis of radiation dermatitis with a topical cortisone cream. Potera, M.E., Lookingbill, D.P., Stryker, J.A. Radiology. (1982) [Pubmed]
  37. Immunoglobulin A deposition in jejunal mucosa of children with dermatitis herpetiformis. Kárpáti, S., Kósnai, I., Török, E., Kovács, J.B. J. Invest. Dermatol. (1988) [Pubmed]
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