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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Tolazamide-induced cholestasis.

The sulfonylurea hypoglycemic agent tolazamide is thought to be a rare cause of jaundice and to exhibit no hepatic cross-sensitivity with other sulfonylurea compounds. We have described a patient who had self-limited cholestatic jaundice after treatment with chlorpropamide. Subsequent treatment with tolazamide resulted in recurrence of jaundice, which disappeared after cessation of treatment. Tolazamide may exhibit hepatic cross-sensitivity with chlorpropamide.[1]


  1. Tolazamide-induced cholestasis. Bridges, M.E., Pittman, F.E. South. Med. J. (1980) [Pubmed]
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