Regional distribution of glutathione reductase in the adult rat brain.
Glutathione reductase was measured in 10 selected areas of the adult rat brain. Activitives varied over a 2.5-fold range. The caudate-putamen and cortical areas contained the highest activities. Several gray matter structures contained intermediate activities. The substantia nigra and the corpus callosum, a white matter structure, contained the lowest activities. The caudate-putamen, a catecholamine rich area, may produce H2O2 via MAO and would require glutathione reductase to recycle glutathione oxidized by glutathione peroxidase. However, the distribution of glutathione reductase activity also suggests a role in reducing oxidants formed during tissue respiration.[1]References
- Regional distribution of glutathione reductase in the adult rat brain. Brannan, T.S., Maker, H.S., Raes, I., Weiss, C. Brain Res. (1980) [Pubmed]
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