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Gene Review

Gpx1  -  glutathione peroxidase 1

Rattus norvegicus

Synonyms: Cellular glutathione peroxidase, GPx-1, GSHPx, GSHPx-1, Glutathione peroxidase 1
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Disease relevance of Gpx1


Psychiatry related information on Gpx1


High impact information on Gpx1


Chemical compound and disease context of Gpx1


Biological context of Gpx1


Anatomical context of Gpx1


Associations of Gpx1 with chemical compounds


Physical interactions of Gpx1


Enzymatic interactions of Gpx1


Regulatory relationships of Gpx1


Other interactions of Gpx1

  • This study reports evidence of both common sites of Gpx1 and Gpx2 expression in rat colon and sites that are exclusive to each isoform [25].
  • In conclusion, the protective effect of SnCl2 on K2Cr2O7-induced nephrotoxicity is associated with HO-1 induction and not with other antioxidant enzymes (Cu,Zn-SOD, Mn-SOD, GPx, GR, and CAT) and SnCl2 has a preventive and not a therapeutic effect on renal damage induced by K2Cr2O7 [39].

Analytical, diagnostic and therapeutic context of Gpx1

  • Semi-quantitative PCR performed previously demonstrated RNA expression of Gpx1 and Gpx2 in proximal, transverse and distal colon [25].
  • In rats treated with GM (70 mg/kg/12 h/4 days/s.c.), ARF was evident by the: (i) decrease in creatinine clearance and increase in blood urea nitrogen, (ii) decrease in blood glutathione peroxidase (GPx) activity and increase in urinary excretion of N-acetyl-beta-D-glucosaminidase and total protein, and (iii) necrosis of proximal tubular cells [23].
  • Activities of GPx, SOD and CAT were higher in groups receiving DOX and/or DOX plus melatonin than in control groups [40].
  • Western blot analysis of cytoplasm for GPX and CuZn SOD showed a significant decrease in GPX and CuZn SOD proteins [41].
  • Endotracheal bleomycin administration alone caused significant reductions in catalase activity at 2 days and 2 weeks after treatment, whereas glutathione peroxidase activity increased above control untreated animals at 2 and 4 weeks, respectively [42].


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  9. Effects of crocetin on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats. Wang, C.J., Shiow, S.J., Lin, J.K. Carcinogenesis (1991) [Pubmed]
  10. Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region. Berry, M.J., Banu, L., Chen, Y.Y., Mandel, S.J., Kieffer, J.D., Harney, J.W., Larsen, P.R. Nature (1991) [Pubmed]
  11. Defective microbicidal activity in glutathione peroxidase-deficient neutrophils of selenium-deficient rats. Serfass, R.E., Ganther, H.E. Nature (1975) [Pubmed]
  12. Pertussis toxin treatment alters manganese superoxide dismutase activity in lung. Evidence for lung oxygen toxicity in air-breathing rats. Clerch, L.B., Neithardt, G., Spencer, U., Melendez, J.A., Massaro, G.D., Massaro, D. J. Clin. Invest. (1994) [Pubmed]
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  14. Differential effect of dietary methionine on the biopotency of selenomethionine and selenite in cancer chemoprevention. Ip, C. J. Natl. Cancer Inst. (1988) [Pubmed]
  15. Cardiac and renal antioxidant enzymes and effects of tempol in hyperthyroid rats. Moreno, J.M., Rodríguez Gómez, I., Wangensteen, R., Osuna, A., Bueno, P., Vargas, F. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  16. Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats. Bellissimo, M.I., Amado, D., Abdalla, D.S., Ferreira, E.C., Cavalheiro, E.A., Naffah-Mazzacoratti, M.G. Epilepsy Res. (2001) [Pubmed]
  17. Poor correlation between oxygen toxicity and activity of glutathione peroxidase. Ospital, J.J., Kasuyama, R.S., Tierney, D.F. Exp. Lung Res. (1983) [Pubmed]
  18. Effect of melatonin against oxidative stress in ultraviolet-B exposed rat lens. Bardak, Y., Ozertürk, Y., Ozgüner, F., Durmuş, M., Delibaş, N. Curr. Eye Res. (2000) [Pubmed]
  19. Gene expression of antioxidant enzymes in experimental diabetic neuropathy. Kishi, Y., Nickander, K.K., Schmelzer, J.D., Low, P.A. J. Peripher. Nerv. Syst. (2000) [Pubmed]
  20. Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues. Sun, X., Li, X., Moriarty, P.M., Henics, T., LaDuca, J.P., Maquat, L.E. Mol. Biol. Cell (2001) [Pubmed]
  21. Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species. Tiedge, M., Lortz, S., Munday, R., Lenzen, S. Diabetes (1998) [Pubmed]
  22. Effect of free radical scavengers on diaphragmatic contractility in septic peritonitis. Fujimura, N., Sumita, S., Aimono, M., Masuda, Y., Shichinohe, Y., Narimatsu, E., Namiki, A. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  23. Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage. Maldonado, P.D., Barrera, D., Rivero, I., Mata, R., Medina-Campos, O.N., Hernández-Pando, R., Pedraza-Chaverrí, J. Free Radic. Biol. Med. (2003) [Pubmed]
  24. Pro-oxidant activity of aluminum in the rat hippocampus: gene expression of antioxidant enzymes after melatonin administration. Gómez, M., Esparza, J.L., Nogués, M.R., Giralt, M., Cabré, M., Domingo, J.L. Free Radic. Biol. Med. (2005) [Pubmed]
  25. Novel sites of cytosolic glutathione peroxidase expression in colon. Drew, J.E., Farquharson, A.J., Arthur, J.R., Morrice, P.C., Duthie, G.G. FEBS Lett. (2005) [Pubmed]
  26. Modulation of azaserine-induced pancreatic foci by phenolic antioxidants in rats. Roebuck, B.D., MacMillan, D.L., Bush, D.M., Kensler, T.W. J. Natl. Cancer Inst. (1984) [Pubmed]
  27. Antioxidant gene expression in rat lung after exposure to cigarette smoke. Gilks, C.B., Price, K., Wright, J.L., Churg, A. Am. J. Pathol. (1998) [Pubmed]
  28. Tolerance of rats to hyperoxia. Lung antioxidant enzyme gene expression. Clerch, L.B., Massaro, D. J. Clin. Invest. (1993) [Pubmed]
  29. Effects of iron loading on free radical scavenging enzymes and lipid peroxidation in rat liver. Fletcher, L.M., Roberts, F.D., Irving, M.G., Powell, L.W., Halliday, J.W. Gastroenterology (1989) [Pubmed]
  30. Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats. Hill, M.F., Singal, P.K. Am. J. Pathol. (1996) [Pubmed]
  31. Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro. Lampe, M.A., Kammerer, R.C. Carcinogenesis (1987) [Pubmed]
  32. An investigation into the effect of sulfonylurea glyburide on glutathione peroxidase activity in streptozotocin-induced diabetic rat muscle tissue. Kiliç, N., Malhatun, E., Elmali, E., Altan, N. Gen. Pharmacol. (1998) [Pubmed]
  33. Regional distribution of glutathione reductase in the adult rat brain. Brannan, T.S., Maker, H.S., Raes, I., Weiss, C. Brain Res. (1980) [Pubmed]
  34. Increased spontaneous chemiluminescence from liver homogenates and isolated hepatocytes upon inhibition of O2- and H2O2 utilization. Turrens, J.F., Giulivi, C., Boveris, A. Journal of free radicals in biology & medicine. (1986) [Pubmed]
  35. Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats: role of oxygen free radicals generation. Villegas, I., Martín, A.R., Toma, W., de la Lastra, C.A. Eur. J. Pharmacol. (2004) [Pubmed]
  36. Dietary selenium intake controls rat plasma selenoprotein P concentration. Yang, J.G., Hill, K.E., Burk, R.F. J. Nutr. (1989) [Pubmed]
  37. Testis glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase activities in aminoguanidine-treated diabetic rats. Unlüçerçi, Y., Bekpinar, S., Koçak, H. Arch. Biochem. Biophys. (2000) [Pubmed]
  38. Involvement of superoxide dismutase and glutathione peroxidase in attenuation of radiation-induced hyperthermia by interleukin-1 alpha in rats. Kandasamy, S.B., Kumar, K.S., Harris, A.H. Brain Res. (1993) [Pubmed]
  39. Protective effect of SnCl2 on K2Cr2O7-induced nephrotoxicity in rats: the indispensability of HO-1 preinduction and lack of association with some antioxidant enzymes. Barrera, D., Maldonado, P.D., Medina-Campos, O.N., Hernández-Pando, R., Ibarra-Rubio, M.E., Pedraza-Chaverrí, J. Life Sci. (2003) [Pubmed]
  40. Melatonin stimulates the activity of protective antioxidative enzymes in myocardial cells of rats in the course of doxorubicin intoxication. Dziegiel, P., Murawska-Ciałowicz, E., Jethon, Z., Januszewska, L., Podhorska-Okołów, M., Surowiak, P., Zawadzki, M., Rabczyński, J., Zabel, M. J. Pineal Res. (2003) [Pubmed]
  41. Antioxidant enzymes in ciprofibrate-induced oxidative stress. Dhaunsi, G.S., Singh, I., Orak, J.K., Singh, A.K. Carcinogenesis (1994) [Pubmed]
  42. Inhibition of bleomycin-induced pulmonary fibrosis by lipopolysaccharide. Phan, S.H., Fantone, J.C. Lab. Invest. (1984) [Pubmed]
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