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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Moduretic-induced metabolic acidosis and hyperkalaemia.

A patient who developed significant metabolic acidosis and severe hyperkalaemia while taking Moduretic (amiloride and hydrochlorothiazide) is reported. During the period of hyperkalaemia (maximum potassium 7-6 mmol/l) the patient's whole body potassium content was normal. His acid-base balance and serum potassium returned to normal some 10 days after stopping the drug. The possible mechanism of acidosis and hyperkalaemia in this patient is discussed.[1]


  1. Moduretic-induced metabolic acidosis and hyperkalaemia. Wan, H.H., Lye, M.D. Postgraduate medical journal. (1980) [Pubmed]
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