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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Kinetics of drug decomposition. Part 62. Kinetics of penicillin G potassium salt (PGP) thermal degradation in solid phase.

The kinetics of degradation of penicillin G K salt (PGP) in solid phase in the temperature range 70-140 degrees C were investigated. The obtained sigmoidal curves were interpreted in terms of the Prout-Tompkins kinetics. The appropriate mathematical equations were derived for the induction and acceleration periods which enable to calculate the degradation half-time, t0.1 value and the induction time (t'). The Arrhenius plot shows the isokinetic point where the rates of reaction for both periods are identical.[1]

References

  1. Kinetics of drug decomposition. Part 62. Kinetics of penicillin G potassium salt (PGP) thermal degradation in solid phase. Pawełczyk, E., Płotkowiak, Z., Knitter, K., Kozakiewicz-Wegner, B. Polish journal of pharmacology and pharmacy. (1980) [Pubmed]
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