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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Acute tryptophan depletion and increased food intake and irritability in bulimia nervosa.

OBJECTIVE: Data suggest that serotonin activity is reduced in women at normal weight who have bulimia nervosa. The authors tested whether acute perturbations in serotonin activity could alter short-term eating behavior and mood. METHOD: They examined the effect of acute tryptophan depletion in 10 women with and 10 women without bulimia nervosa. RESULTS: Women with bulimia nervosa exhibited an increase in caloric intake and mood irritability after acute tryptophan depletion. CONCLUSIONS: These results indicate that women with bulimia nervosa have an exaggerated or pathological response to transient alterations in serotonin activity.[1]

References

  1. Acute tryptophan depletion and increased food intake and irritability in bulimia nervosa. Weltzin, T.E., Fernstrom, M.H., Fernstrom, J.D., Neuberger, S.K., Kaye, W.H. The American journal of psychiatry. (1995) [Pubmed]
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