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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Paroxysmal hypertension in a C4 spinal cord injury--a case report.

Hypertension in a patient with acute spinal cord injury is commonly caused by autonomic dysreflexia, which is a syndrome of paroxysmal hypertension associated with headaches, relative bradycardia and vasomotor instability secondary to sympathetic overactivity. Life-threatening complications such as seizures and intracerebral haemorrhage are largely preventable. We report both acute and chronic forms of autonomic dysreflexia due to underlying urinary and faecal impaction in a 33-year-old female with traumatic C4 quadriplegia. She was successfully managed with a combination of physical and pharmacological measures including calcium channel and sympathetic blockers.[1]


  1. Paroxysmal hypertension in a C4 spinal cord injury--a case report. Chua, K.S., Kong, K.H., Tan, E.S. Ann. Acad. Med. Singap. (1995) [Pubmed]
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