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Disease relevance of Quadriplegia


Psychiatry related information on Quadriplegia


High impact information on Quadriplegia

  • Transient areflexia and quadriplegia following metrizamide myelography [10].
  • The cases in which the territories of the three cerebellar arteries were affected presented in deep coma, together with tetraplegia in some patients [11].
  • We report a case of quadriplegia complicating OPLL in a patient with DISH [12].
  • The osmotic and cardiovascular control of arginine vasopressin (AVP) secretion, and the effect of this hormone on cardiovascular regulation were assessed both in normal controls and in subjects with tetraplegia [13].
  • The disorder is rare, probably misdiagnosed initially as spastic quadriplegia, and later as epilepsy [14].

Chemical compound and disease context of Quadriplegia


Biological context of Quadriplegia


Anatomical context of Quadriplegia

  • The clinical manifestations included the rostral basilar artery syndrome (8); coma at onset, often with tetraplegia (11); cerebellar and vestibular signs (9, with delayed coma due to cerebellar swelling in 6); and, in only 1 patient, the "classic" syndrome of the SCA [25].
  • This report describes a patient presenting with a spastic quadriplegia who was found to have both diffuse idiopathic skeletal hyperostosis (DISH) and ossification of the posterior longitudinal ligament (OPLL) in the cervical spine [26].
  • The results in ten arms of nine patients who had post-traumatic tetraplegia at the fifth or sixth cervical level were reviewed after combined transfer of the brachioradialis to the flexor pollicis longus and of the posterior part of the deltoid to the triceps tendon to restore key pinch and extension of the elbow [27].
  • When compared with matched nondisabled controls, young survivors of quadriplegia have reduced CD4:CD8 ratios, suppressed proliferative responses to mitogen challenge, reduced number and cytotoxicity of CD3-CD56+ (NK) cells, and elevation of the soluble IL-2 receptor [28].
  • We report on a child with lissencephaly type I, abnormal lymph nodes, and immunodeficiency, associated with recurrent infections, autoimmune disease, spastic tetraplegia, and psychomotor retardation [29].

Gene context of Quadriplegia

  • For children less than 32 weeks, FVL homozygosity may be associated with an increase in the risk of developing quadriplegia (OR 9.12, 95% CI 0.86-53.71) [24].
  • In 50 patients with renal lithiasis caused by diseases other than 1 degrees HPT (anatomical variations, pyelonephritis, immobilization after tetraplegia) the ratio cyclic AMP/GFR was not raised [30].
  • We describe a 13-year-old boy with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) who experienced a stroke-like episode resulting in severe mental regression and quadriplegia [31].
  • METHODS: The National Trauma Data Bank study, which included patients >14 years of age and had injury severity score (ISS) >15, were alive on admission and had at least one of the following severe injuries: aortic, vena cava, iliac vessels, cardiac, grade IV/V liver injuries, quadriplegia, or complex pelvic fractures [32].
  • Two related infants with microcephaly, spastic quadriplegia, and profound retardation are reported [33].

Analytical, diagnostic and therapeutic context of Quadriplegia

  • Immobilization with pancuronium and controlled ventilation ameliorate deficit to an ND score of 19% (P less than 0.05) (including quadriparesis); this became control 2 protocol [34].
  • Patients were initially categorized by presence or absence of conditions requiring specialized care (e.g., nutritional intake problems, quadriplegia, wounds or lesions, coma, and physical rehabilitation potential) [35].
  • Anterior decompression and arthrodesis of the cervical spine: long-term motor improvement. Part II--Improvement in complete traumatic quadriplegia [36].
  • Electric wheelchair propulsion using a hand control in C4 quadriplegia. A case report [37].
  • For more severely disabled persons with C4 quadriplegia, the authors adapted this vacuum pick-up system by substituting a lightweight, tubular aluminum mouthstick in place of the orthosis as the primary grasping utensil [38].


  1. Acetazolamide-induced weakness in paramyotonia congenita. Riggs, J.E., Griggs, R.C., Moxley, R.T. Ann. Intern. Med. (1977) [Pubmed]
  2. Pontine hemorrhage in a patient with pheochromocytoma. Scardigli, K., Biller, J., Brooks, M.H., Cespedes, L.E., Posniak, H.V. Arch. Intern. Med. (1985) [Pubmed]
  3. A novel antineuronal antibody in a motor neuron syndrome associated with breast cancer. Ferracci, F., Fassetta, G., Butler, M.H., Floyd, S., Solimena, M., De Camilli, P. Neurology (1999) [Pubmed]
  4. The clinical manifestations of pontine hemorrhage. Kushner, M.J., Bressman, S.B. Neurology (1985) [Pubmed]
  5. Medial medullary infarction from fibrocartilaginous embolism to the anterior spinal artery. Kase, C.S., Varakis, J.N., Stafford, J.R., Mohr, J.P. Stroke (1983) [Pubmed]
  6. HDL cholesterol across a spectrum of physical activity from quadriplegia to marathon running. LaPorte, R.E., Brenes, G., Dearwater, S., Murphy, M.A., Cauley, J.A., Dietrick, R., Robertson, R. Lancet (1983) [Pubmed]
  7. Sulfite oxidase deficiency: clinical, neuroradiologic, and biochemical features in two new patients. Brown, G.K., Scholem, R.D., Croll, H.B., Wraith, J.E., McGill, J.J. Neurology (1989) [Pubmed]
  8. Bilateral frontal polymicrogyria: a newly recognized brain malformation syndrome. Guerrini, R., Barkovich, A.J., Sztriha, L., Dobyns, W.B. Neurology (2000) [Pubmed]
  9. Neurodevelopmental disorders in males related to the gene causing Rett syndrome in females (MECP2). Moog, U., Smeets, E.E., van Roozendaal, K.E., Schoenmakers, S., Herbergs, J., Schoonbrood-Lenssen, A.M., Schrander-Stumpel, C.T. Eur. J. Paediatr. Neurol. (2003) [Pubmed]
  10. Transient areflexia and quadriplegia following metrizamide myelography. Peroutka, S.J., Ullrich, C.G., Fisher, R.S., Suss, R.A., Brooks, B.R. Ann. Neurol. (1982) [Pubmed]
  11. Cerebellar infarction in the territory of the anterior and inferior cerebellar artery. A clinicopathological study of 20 cases. Amarenco, P., Hauw, J.J. Brain (1990) [Pubmed]
  12. Sudden quadriplegia complicating ossification of the posterior longitudinal ligament and diffuse idiopathic skeletal hyperostosis. Pouchot, J., Watts, C.S., Esdaile, J.M., Hill, R.O. Arthritis Rheum. (1987) [Pubmed]
  13. Neuroendocrine control of vasopressin secretion and its effect on blood pressure in subjects with spinal cord transection. Poole, C.J., Williams, T.D., Lightman, S.L., Frankel, H.L. Brain (1987) [Pubmed]
  14. Startle disease or hyperekplexia: further delineation of the syndrome. Andermann, F., Keene, D.L., Andermann, E., Quesney, L.F. Brain (1980) [Pubmed]
  15. Flaccid quadriparesis associated with Yersinia enterocolitis-induced hypokalemia. Orman, R.A., Lewis, J.B. Arch. Intern. Med. (1989) [Pubmed]
  16. Absence of detectable melatonin and preservation of cortisol and thyrotropin rhythms in tetraplegia. Zeitzer, J.M., Ayas, N.T., Shea, S.A., Brown, R., Czeisler, C.A. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  17. Circadian blood pressure rhythm in patients with higher and lower spinal cord injury: simultaneous evaluation of autonomic nervous activity and physical activity. Munakata, M., Kameyama, J., Kanazawa, M., Nunokawa, T., Moriai, N., Yoshinaga, K. J. Hypertens. (1997) [Pubmed]
  18. Toxic effects of sulphite in combination with peroxynitrite on neuronal cells. Reist, M., Marshall, K.A., Jenner, P., Halliwell, B. J. Neurochem. (1998) [Pubmed]
  19. Acute steroid-induced tetraplegia following status asthmaticus. Kaplan, P.W., Rocha, W., Sanders, D.B., D'Souza, B., Spock, A. Pediatrics (1986) [Pubmed]
  20. Hypoxic-ischemic fetal insult resulting from maternal aortic root replacement, with normal fetal heart rate at term. Mul, T.F., van Herwerden, L.A., Cohen-Overbeek, T.E., Catsman-Berrevoets, C.E., Lotgering, F.K. Am. J. Obstet. Gynecol. (1998) [Pubmed]
  21. Heterotopic ossification in the hand of a patient with spinal cord injury. Lynch, C., Pont, A., Weingarden, S.I. Archives of physical medicine and rehabilitation. (1981) [Pubmed]
  22. Fatal bilateral adrenal hemorrhage following acute toluene poisoning: a case report. Kamijo, Y., Soma, K., Hasegawa, I., Ohwada, T. J. Toxicol. Clin. Toxicol. (1998) [Pubmed]
  23. Three dimensional upper extremity motion during manual wheelchair propulsion in men with different levels of spinal cord injury. Newsam, C.J., Rao, S.S., Mulroy, S.J., Gronley, J.K., Bontrager, E.L., Perry, J. Gait & posture. (1999) [Pubmed]
  24. Associations between inherited thrombophilias, gestational age, and cerebral palsy. Gibson, C.S., MacLennan, A.H., Hague, W.M., Haan, E.A., Priest, K., Chan, A., Dekker, G.A. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  25. Cerebellar infarction in the territory of the superior cerebellar artery: a clinicopathologic study of 33 cases. Amarenco, P., Hauw, J.J. Neurology (1990) [Pubmed]
  26. Cervical myelopathy, ossification of the posterior longitudinal ligament, and diffuse idiopathic skeletal hyperostosis: problems in investigation. Griffiths, I.D., Fitzjohn, T.P. Ann. Rheum. Dis. (1987) [Pubmed]
  27. Single-stage reconstruction of key pinch and extension of the elbow in tetraplegic patients. Paul, S.D., Gellman, H., Waters, R., Willstein, G., Tognella, M. The Journal of bone and joint surgery. American volume. (1994) [Pubmed]
  28. Immune responses to nervous system decentralization and exercise in quadriplegia. Nash, M.S. Medicine and science in sports and exercise. (1994) [Pubmed]
  29. Lissencephaly, abnormal lymph nodes, and T-cell deficiency in one patient. Krawinkel, M.B., Ernst, M., Feller, A., Flad, H.D., Mueller-Hermelink, H.K., Ulmer, A.J., Schaub, J. Am. J. Med. Genet. (1989) [Pubmed]
  30. Hyperparathyoidism: influence of glomerular filtration rate on urinary excretion of cyclic AMP. Schmidt-Gayk, H., Stengel, R., Haueisen, H., Hüfner, M., Ritz, E., Jakobs, K.H. Klin. Wochenschr. (1977) [Pubmed]
  31. Detection of 14-3-3 protein in the cerebrospinal fluid in mitochondrial encephalopathy with lactic acidosis and stroke-like episodes. Fujii, K., Tanabe, Y., Kobayashi, K., Uchikawa, H., Kohno, Y. J. Neurol. Sci. (2005) [Pubmed]
  32. The effect of trauma center designation and trauma volume on outcome in specific severe injuries. Demetriades, D., Martin, M., Salim, A., Rhee, P., Brown, C., Chan, L. Ann. Surg. (2005) [Pubmed]
  33. Familial calcification of the basal ganglia with cerebrospinal fluid pleocytosis. Mehta, L., Trounce, J.Q., Moore, J.R., Young, I.D. J. Med. Genet. (1986) [Pubmed]
  34. Effect of postcirculatory-arrest life-support on neurological recovery in monkeys. Bleyaert, A., Safar, P., Nemoto, E., Moossy, J., Sassano, J. Crit. Care Med. (1980) [Pubmed]
  35. Nursing home case mix. Patient classification by nursing resource use. Arling, G., Nordquist, R.H., Brant, B.A., Capitman, J.A. Medical care. (1987) [Pubmed]
  36. Anterior decompression and arthrodesis of the cervical spine: long-term motor improvement. Part II--Improvement in complete traumatic quadriplegia. Anderson, P.A., Bohlman, H.H. The Journal of bone and joint surgery. American volume. (1992) [Pubmed]
  37. Electric wheelchair propulsion using a hand control in C4 quadriplegia. A case report. McClay, I. Physical therapy. (1983) [Pubmed]
  38. Vacuum as a grasping force. O'Reagan, J.R., Law, D.F., Bresler, M., Reger, S.I. Archives of physical medicine and rehabilitation. (1981) [Pubmed]
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