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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Isolation and mapping of a gene encoding a novel human ADP-ribosylation factor on chromosome 17q12-q21.

A gene encoding a low-molecular-weight GTP-binding protein was isolated from a retinal cDNA library and mapped to human chromosome 17q12-q21. Comparison of the predicted protein with the protein databases revealed striking homology to the family of ADP-ribosylation factors (ARFs), which are thought to be involved in membrane trafficking and protein secretion. The greatest homology observed was with the rat ARF-like 4 protein (ARL4), with which it shared 58% identity, while the more highly conserved human ARF1 and ARF3 proteins each shared 46% identity. Inspection of the predicted new protein showed that it contained each of the six conserved motifs that are required for guanine nucleotide binding and hydrolysis, and thus it is probably a novel ARF isoform. We have designated the new protein and its corresponding gene ARF4L.[1]

References

  1. Isolation and mapping of a gene encoding a novel human ADP-ribosylation factor on chromosome 17q12-q21. Smith, S.A., Holik, P.R., Stevens, J., Melis, R., White, R., Albertsen, H. Genomics (1995) [Pubmed]
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