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Gene Review

ARL4D  -  ADP-ribosylation factor-like 4D

Homo sapiens

Synonyms: ADP-ribosylation factor-like protein 4D, ADP-ribosylation factor-like protein 4L, ARF4L, ARL6
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Disease relevance of ARL4D

  • These results indicate that these two ARF4L peptides could be targets for immunotherapy of HLA-A2+ patients with brain tumors [1].
  • To elucidate the molecular mechanisms underlying post-ischemic phenomena including delayed neuronal death, we screened for genes which were induced in the hippocampus after transient global ischemia in the Mongolian gerbil by a differential display method, and cloned a gerbil homologue of human ADP-ribosylation factor 4L (ARF4L) [2].
  • The expression of ARF4L mRNA was elevated at 12 h after hypoxia exposure, similarly to HSP70 [2].

High impact information on ARL4D


Biological context of ARL4D


Anatomical context of ARL4D

  • In situ hybridization analysis indicated that the expression of ARF4L mRNA was elevated in neurons of the dentate gyrus (DG) and CA1 regions [2].
  • These findings indicate that ARF4L drive the transport of cargo protein and subsequent fusion of recycling vesicles with the plasma membrane for maintenance of the cell surface [3].
  • Here, we investigated the expression pattern of ARL6 during early mouse development by whole-mount in situ hybridization and found that interestingly, ARL6 mRNA was localized around the node at 7.0-7.5 days post coitum (dpc) embryos, while weak expression was also found in the ectoderm [4].


  1. Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumors. Nonaka, Y., Tsuda, N., Shichijo, S., Ito, M., Maeda, Y., Harada, M., Kamura, T., Shigemori, M., Itoh, K. Tissue Antigens (2002) [Pubmed]
  2. Expression of an ADP-ribosylation factor like gene, ARF4L, is induced after transient forebrain ischemia in the gerbil. Katayama, T., Imaizumi, K., Tsuda, M., Mori, Y., Takagi, T., Tohyama, M. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  3. Role of ARF4L in recycling between endosomes and the plasma membrane. Katayama, T., Imaizumi, K., Yoneda, T., Taniguchi, M., Honda, A., Manabe, T., Hitomi, J., Oono, K., Baba, K., Miyata, S., Matsuzaki, S., Takatsuji, K., Tohyama, M. Cell. Mol. Neurobiol. (2004) [Pubmed]
  4. Expression of ADP-ribosylation factor (ARF)-like protein 6 during mouse embryonic development. Takada, T., Iida, K., Sasaki, H., Taira, M., Kimura, H. Int. J. Dev. Biol. (2005) [Pubmed]
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