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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis.

The identification of key antigens in human autoimmune diseases is a crucial step towards the development of specific intervention. The autoantigen(s) relevant to multiple sclerosis ( MS) probably reside in myelin of the central nervous system, the target of the disease. Here we examine proliferative responses of human peripheral blood T cells to the complete collection of myelin proteins fractionated by reversed-phase high-performance liquid chromatography. Myelin isolated from MS-affected brain contained a single protein fraction to which T cells from MS patients and from healthy controls showed dominant responses. This highly immunogenic protein was identified as alpha B-crystallin, a small heat-shock protein. Immunohistochemical examination of MS lesions revealed the presence of oligodendrocytes and astrocytes with raised alpha B-crystallin expression, which were not found in unaffected myelin. Our findings indicate that alpha B-crystallin serves as immunodominant myelin antigen to human T cells when expressed at the elevated levels found in active MS lesions.[1]

References

  1. The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis. van Noort, J.M., van Sechel, A.C., Bajramovic, J.J., el Ouagmiri, M., Polman, C.H., Lassmann, H., Ravid, R. Nature (1995) [Pubmed]
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