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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q.

Brain factor-1 (BF-1) is a member of the fork head gene family which shows expression restricted to the neurons of the developing telencephalon in rodents and man. We have isolated a second human gene (HBF-2), which is also strongly expressed in embryonic brain and has very high homology to both the rat and human brain factor-1 genes and the retroviral oncogene qin. The HBF-2 cDNA was isolated from a human fetal brain expression library and contains a putative open reading frame of 479 amino acids. The HBF-2 gene is strongly expressed in fetal brain and also with lower levels of expression in several adult tissues. At the genomic level the gene for HBF-1 contains an 500 bp intron situated between the DNA binding domain II and the fork head domain while that of HBF-2 is intronless. The two genes are clustered on human chromosome 14q11-13.[1]

References

  1. The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q. Wiese, S., Murphy, D.B., Schlung, A., Burfeind, P., Schmundt, D., Schnülle, V., Mattei, M.G., Thies, U. Biochim. Biophys. Acta (1995) [Pubmed]
 
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