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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Sequential levels of ceftriaxone in intervertebral disc removed as part of scoliosis surgery.

A single intravenous loading dose of 1 g ceftriaxone was injected at different intervals before surgery for correction of spinal scoliosis. Serum and concomitant disc samples were obtained and assay was performed using high-pressure liquid chromatography. Data showed that the antibiotic levels in intervertebral disc space reached 3.5 mcg/mg, which is above the minimum inhibitory concentration for most of the relevant pathogens, as early as 1 hour after intravenous administration. These therapeutic levels were maintained for more than 5 hours, an accepted period for most spinal surgical procedures.[1]

References

  1. Sequential levels of ceftriaxone in intervertebral disc removed as part of scoliosis surgery. Lang, R., Folman, Y., Ravid, M., Bental, T., Gepstein, R. Clin. Orthop. Relat. Res. (1995) [Pubmed]
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