Disease relevance of Scoliosis

• Charcot-Marie-Tooth disease type 4C (CMT4C) is a childhood-onset demyelinating form of hereditary motor and sensory neuropathy associated with an early-onset scoliosis and a distinct Schwann cell pathology [1].
• The identification of the ky gene will allow detailed analysis of the impact of primary myopathy on idiopathic scoliosis in mice and man [2].
• Other features that are more variable in expressivity include dilated cardiomyopathy, hypertriglyceridemia, hypercholesterolemia, scoliosis, developmental delay and pulmonary and urological dysfunctions [3].
• Associated symptoms, such as muscle wasting, sensory disturbances, foot deformity, scoliosis and electrocardiographic abnormalities were encountered less frequently in EOCA than in FA patients [4].
• Unlike COPD, pulmonary function following ARF in kyphosis or scoliosis deteriorates at a slower than expected rate and, in fact, may improve with treatment over many years [5].

Psychiatry related information on Scoliosis

• We report on an individual with severe mental retardation, seizures, microcephaly, unusual face, scoliosis, and cleft feet and cleft right hand [6].
• We recently had an opportunity to study the status of bone remodeling by quantitative bone histomorphometry in three girls ages 9.75, 13.5, and 14 years, with typical Rett syndrome who required scoliosis surgery.Anterior iliac crest bone biopsies were performed 1-2 days after double labeling of the bone surfaces with tetracycline [7].

High impact information on Scoliosis

• The aims were to examine the effects of scoliosis (angle), and age on lung volumes, elastic properties of the respiratory system, and the ventilatory response to CO2 [8].
• In the A-T families, idiopathic scoliosis and vertebral anomalies were in excess, while genitourinary and distal limb malformations were found in the FA families [9].
• Sim2 mutants also develop congenital scoliosis, reflected by the unequal sizes of the left and right vertebrae and ribs [10].
• RESULTS: Mild scoliosis was noticed in the proband at the age of 6 years, and at the age of 7 years large Schmorl's nodes were found in the vertebrae L1-2 [11].
• There was no significant association between BMD and scoliosis, nor between BMD and fracture history [12].

Chemical compound and disease context of Scoliosis

• These results confirm our previous observations in rats, and also support our hypothesis that melatonin as well as the bipedal ambulation appear to play a critical pathogenic role in scoliosis in experimental mammals [13].
• The authors hypothesized that administration of tranexamic acid would reduce bleeding and transfusion requirements during scoliosis surgery [14].
• The typical scoliosis condition associated with severe vitamin C deficiency in fish occurred in the nonsupplemented groups in the study with practical diets [15].
• Proceedings: Selective denervation in the treatment of paralytic scoliosis based on electromyographic studies of erector spinae and quadratus lumborum [16].
• The severity of the scoliosis was closely related to a decrease in extracellular striatal dopamine measured with microdialysis and to the development of postsynaptic dopamine receptor supersensitivity, functionally evaluated with rotational behaviour elicited with apomorphine [17].

Biological context of Scoliosis

• To clarify the relation between resting energy expenditure (REE), nutritional state, and OCB these indices were measured in patients with respiratory impairment and an increased OCB due to COPD, scoliosis, and thoracoplasty [18].
• The effects of 0.5, 0.75, and 1 MAC of halothane, enflurane, and isoflurane in 60% nitrous oxide on somatosensory cortical evoked potentials were studied in 30 patients undergoing corrective surgery for scoliosis [19].
• The effect of intravenous lidocaine on somatosensory evoked potentials during scoliosis surgery [20].
• Total serum calcium, its fractions and serum citrate concentrations were measured in children receiving massive blood transfusion for scoliosis surgery, and in other children undergoing open heart surgery with cardiopulmonary bypass [21].
• Adolescent-onset scoliosis may represent part of the dystonia phenotype in this family [22].

Anatomical context of Scoliosis

• In addition to the induction of scoliosis in chickens by pinealectomy (PINX), we previously demonstrated that removal of the pineal gland also produces scoliosis in bipedal rats, which can be inhibited by melatonin treatment [13].
• That vitamin B-6, manganese and copper are dietary factors important to the expression of scoliosis may be related to their roles in the formation of connective tissue components, such as matrix glycoproteins, collagen or proteoglycans [23].
• Effect of sevoflurane/nitrous oxide versus propofol anaesthesia on somatosensory evoked potential monitoring of the spinal cord during surgery to correct scoliosis [24].
• Trachea and bronchi were reinforced with surrounding acrylate mesh before surgical treatment of the scoliosis [25].
• He also had an atrial septal defect, micropenis, small testes, clubfeet, scoliosis, block C2-4, and structural brain abnormalities on MRI [26].

Gene context of Scoliosis

• Novel EGR2 mutation R359Q is associated with CMT type 1 and progressive scoliosis [27].
• We present the first molecular study of congenital scoliosis by analysis of the candidate gene DLL3 and demonstrate one novel missense variant [28].
• We therefore identified PAX1 as a candidate gene in vertebral malformations and congenital scoliosis due to its mutation in the undulated mouse [29].
• Lowe oculocerebrorenal syndrome (OCRL) (MIM 309000) is a rare X-linked multisystem disorder characterized by congenital cataracts, muscular hypotonia, areflexia, mental retardation, maladaptive behavior, renal tubular dysfunction, vitamin-D-resistant rickets, and scoliosis [30].
• In conclusion, a dissociation in the adaptive response of m. erector spinae in scoliosis between mitochondrial enzyme and myoglobin content was demonstrated [31].

Analytical, diagnostic and therapeutic context of Scoliosis

• One patient with COPD, two with scoliosis, two with thoracoplasty, but no controls were hypermetabolic (REE > 110% predicted) [18].
• With the dose used in our study, we conclude that DDAVP does not reduce surgical bleeding in patients undergoing spinal fusion for idiopathic scoliosis [32].
• A randomized trial of tranexamic acid to reduce blood transfusion for scoliosis surgery [33].
• Continuous spinal anesthesia with combined hyperbaric and isobaric bupivacaine in a patient with scoliosis [34].
• This study was designed to compare the effects of propofol and midazolam on CSEP under total intravenous anesthesia during intraoperative monitoring for surgical treatment of scoliosis [35].

References