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MeSH Review

Intervertebral Disk

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Disease relevance of Intervertebral Disk


High impact information on Intervertebral Disk


Chemical compound and disease context of Intervertebral Disk


Biological context of Intervertebral Disk


Anatomical context of Intervertebral Disk


Associations of Intervertebral Disk with chemical compounds


Gene context of Intervertebral Disk


Analytical, diagnostic and therapeutic context of Intervertebral Disk


  1. Nerve ingrowth into diseased intervertebral disc in chronic back pain. Freemont, A.J., Peacock, T.E., Goupille, P., Hoyland, J.A., O'Brien, J., Jayson, M.I. Lancet (1997) [Pubmed]
  2. Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development. Furumoto, T.A., Miura, N., Akasaka, T., Mizutani-Koseki, Y., Sudo, H., Fukuda, K., Maekawa, M., Yuasa, S., Fu, Y., Moriya, H., Taniguchi, M., Imai, K., Dahl, E., Balling, R., Pavlova, M., Gossler, A., Koseki, H. Dev. Biol. (1999) [Pubmed]
  3. Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. Noponen-Hietala, N., Virtanen, I., Karttunen, R., Schwenke, S., Jakkula, E., Li, H., Merikivi, R., Barral, S., Ott, J., Karppinen, J., Ala-Kokko, L. Pain (2005) [Pubmed]
  4. Amyloid in intervertebral discs: a histopathological investigation of surgical material from 100 consecutive operations on herniated discs. Ladefoged, C., Fedders, O., Petersen, O.F. Ann. Rheum. Dis. (1986) [Pubmed]
  5. Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells. Wang, H., Kroeber, M., Hanke, M., Ries, R., Schmid, C., Poller, W., Richter, W. J. Mol. Med. (2004) [Pubmed]
  6. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Seki, S., Kawaguchi, Y., Chiba, K., Mikami, Y., Kizawa, H., Oya, T., Mio, F., Mori, M., Miyamoto, Y., Masuda, I., Tsunoda, T., Kamata, M., Kubo, T., Toyama, Y., Kimura, T., Nakamura, Y., Ikegawa, S. Nat. Genet. (2005) [Pubmed]
  7. An allele of COL9A2 associated with intervertebral disc disease. Annunen, S., Paassilta, P., Lohiniva, J., Perälä, M., Pihlajamaa, T., Karppinen, J., Tervonen, O., Kröger, H., Lähde, S., Vanharanta, H., Ryhänen, L., Göring, H.H., Ott, J., Prockop, D.J., Ala-Kokko, L. Science (1999) [Pubmed]
  8. Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. Schleicher, E.D., Wagner, E., Nerlich, A.G. J. Clin. Invest. (1997) [Pubmed]
  9. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. Antoniou, J., Steffen, T., Nelson, F., Winterbottom, N., Hollander, A.P., Poole, R.A., Aebi, M., Alini, M. J. Clin. Invest. (1996) [Pubmed]
  10. Interaction of the NG2 chondroitin sulfate proteoglycan with type VI collagen. Stallcup, W.B., Dahlin, K., Healy, P. J. Cell Biol. (1990) [Pubmed]
  11. Epidural administration of methylprednisolone and morphine for pain after a spinal operation. A randomized, prospective, comparative study. McNeill, T.W., Andersson, G.B., Schell, B., Sinkora, G., Nelson, J., Lavender, S.A. The Journal of bone and joint surgery. American volume. (1995) [Pubmed]
  12. Halo pin intracranial penetration and epidural abscess in a patient with a previous cranioplasty: case report and review of the literature. Papagelopoulos, P.J., Sapkas, G.S., Kateros, K.T., Papadakis, S.A., Vlamis, J.A., Falagas, M.E. Spine. (2001) [Pubmed]
  13. Nitric oxide induced ectopic firing in a lumbar nerve root with cauda equina compression. Onozawa, T., Atsuta, Y., Sato, M., Ikawa, M., Tsunekawa, H., Feng, X. Clin. Orthop. Relat. Res. (2003) [Pubmed]
  14. Sequential levels of ceftriaxone in intervertebral disc removed as part of scoliosis surgery. Lang, R., Folman, Y., Ravid, M., Bental, T., Gepstein, R. Clin. Orthop. Relat. Res. (1995) [Pubmed]
  15. The effect of prophylactic antibiotics on iatrogenic intervertebral disc infections. a rabbit model. Guiboux, J.P., Cantor, J.B., Small, S.D., Zervos, M., Herkowitz, H.N. Spine. (1995) [Pubmed]
  16. Matrix deposition of tryptophan-containing allelic variants of type IX collagen in developing human cartilage. Matsui, Y., Wu, J.J., Weis, M.A., Pietka, T., Eyre, D.R. Matrix Biol. (2003) [Pubmed]
  17. Gene expression of noncollagenous bone matrix proteins in the limb joints and intervertebral disks of the twy mouse. Ohtsuki, T., Furuya, S., Yamada, T., Nomura, S., Hata, J., Yabe, Y., Hosoda, Y. Calcif. Tissue Int. (1998) [Pubmed]
  18. Anti-apoptotic effects of caspase inhibitors on rat intervertebral disc cells. Park, J.B., Park, I.C., Park, S.J., Jin, H.O., Lee, J.K., Riew, K.D. The Journal of bone and joint surgery. American volume. (2006) [Pubmed]
  19. Diffusivity of ions in agarose gels and intervertebral disc: effect of porosity. Gu, W.Y., Yao, H., Vega, A.L., Flagler, D. Annals of biomedical engineering. (2004) [Pubmed]
  20. Substance P in intervertebral discs. Binding sites on vascular endothelium of the human annulus fibrosus. Ashton, I.K., Walsh, D.A., Polak, J.M., Eisenstein, S.M. Acta orthopaedica Scandinavica. (1994) [Pubmed]
  21. Aggrecan turnover in human intervertebral disc as determined by the racemization of aspartic Acid. Sivan, S.S., Tsitron, E., Wachtel, E., Roughley, P.J., Sakkee, N., van der Ham, F., Degroot, J., Roberts, S., Maroudas, A. J. Biol. Chem. (2006) [Pubmed]
  22. Experimental immunity to the G1 domain of the proteoglycan versican induces spondylitis and sacroiliitis, of a kind seen in human spondylarthropathies. Shi, S., Ciurli, C., Cartman, A., Pidoux, I., Poole, A.R., Zhang, Y. Arthritis Rheum. (2003) [Pubmed]
  23. A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican. Dours-Zimmermann, M.T., Zimmermann, D.R. J. Biol. Chem. (1994) [Pubmed]
  24. Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. Madsen, B., Spencer-Dene, B., Poulsom, R., Hall, D., Lu, P.J., Scott, K., Shaw, A.T., Burchell, J.M., Freemont, P., Taylor-Papadimitriou, J. Mech. Dev. (2002) [Pubmed]
  25. Inhibition of phospholipase A2 purified from human herniated disc. Carabaza, A., Cabré, F., García, A.M., Gómez, M., Sánchez, J., Mauleón, D., Carganico, G. Biochem. Pharmacol. (1993) [Pubmed]
  26. Mast cells in the pathogenesis of chronic back pain: a hypothesis. Freemont, A.J., Jeziorska, M., Hoyland, J.A., Rooney, P., Kumar, S. J. Pathol. (2002) [Pubmed]
  27. The serine proteinase inhibitory proteins of the chondrodystrophoid (beagle) and non-chondrodystrophoid (greyhound) canine intervertebral disc. Melrose, J., Taylor, T.K., Ghosh, P. Electrophoresis (1997) [Pubmed]
  28. In vivo detection of intervertebral disk injury using a radiolabeled monoclonal antibody against keratan sulfate. Kairemo, K.J., Lappalainen, A.K., Kääpä, E., Laitinen, O.M., Hyytinen, T., Karonen, S.L., Grönblad, M. J. Nucl. Med. (2001) [Pubmed]
  29. Proteoglycans of the intervertebral disc. Homology of structure with laryngeal proteoglycans. Stevens, R.L., Ewins, R.J., Revell, P.A., Muir, H. Biochem. J. (1979) [Pubmed]
  30. Human intervertebral disc cells from the annulus: three-dimensional culture in agarose or alginate and responsiveness to TGF-beta1. Gruber, H.E., Fisher, E.C., Desai, B., Stasky, A.A., Hoelscher, G., Hanley, E.N. Exp. Cell Res. (1997) [Pubmed]
  31. Vascular endothelial growth factor (VEGF)-induced angiogenesis in herniated disc resorption. Haro, H., Kato, T., Komori, H., Osada, M., Shinomiya, K. J. Orthop. Res. (2002) [Pubmed]
  32. CD24 is expressed specifically in the nucleus pulposus of intervertebral discs. Fujita, N., Miyamoto, T., Imai, J., Hosogane, N., Suzuki, T., Yagi, M., Morita, K., Ninomiya, K., Miyamoto, K., Takaishi, H., Matsumoto, M., Morioka, H., Yabe, H., Chiba, K., Watanabe, S., Toyama, Y., Suda, T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  33. Immunohistochemical detection of Schwann cells in innervated and vascularized human intervertebral discs. Johnson, W.E., Evans, H., Menage, J., Eisenstein, S.M., El Haj, A., Roberts, S. Spine. (2001) [Pubmed]
  34. Two linkage-region fragments isolated from skeletal keratan sulphate contain a sulphated N-acetylglucosamine residue. Dickenson, J.M., Huckerby, T.N., Nieduszynski, I.A. Biochem. J. (1990) [Pubmed]
  35. Affinity chromatography of serine proteinases from the bovine intervertebral disc on BPTI-Separon HEMA 1000. Stovícková, J., Podrazký, V., Trnavský, K. J. Chromatogr. (1992) [Pubmed]
  36. Cell deformation and micromechanical environment in the intervertebral disc. Duncan, N.A. The Journal of bone and joint surgery. American volume. (2006) [Pubmed]
  37. Immunohistochemical localization of the small proteoglycans decorin and biglycan in human intervertebral discs. Götz, W., Barnert, S., Bertagnoli, R., Miosge, N., Kresse, H., Herken, R. Cell Tissue Res. (1997) [Pubmed]
  38. Enhancement of intervertebral disks with gadolinium complexes: comparison of an ionic and a nonionic medium in an animal model. Ibrahim, M.A., Haughton, V.M., Hyde, J.S. AJNR. American journal of neuroradiology. (1994) [Pubmed]
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