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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The measurement of muscle mass in children using [15N]creatine.

In eight infants and children who had recovered from protein-energy malnutrition (PEM), muscle mass was estimated by measuring creatine turnover by an isotope dilution technique using [15N]creatine, creatine concentration, and urinary creatinine output. Creatine turnover varied from 1.5 to 2.6% of the muscle creatine pool per day and muscle creatine concentration ranged from 1.7 to 3.9 mug/mug muscle mass was between 15% and 37% of total body weight. The results indicate that daily creatinine output is not a reliable indicator of muscle mass in children who have recently recovered from severe PEM.[1]


  1. The measurement of muscle mass in children using [15N]creatine. Picou, D., Reeds, P.J., Jackson, A., Poulter, N. Pediatr. Res. (1976) [Pubmed]
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